Simple Summary Fracture healing is a complex process that includes a framework of events
triggered by tissue injury. Clinical experience with bone healing revealed a series of cellular …

Background Acute bone loss after fracture is associated with various effects on the complete
recovery process and a risk of secondary fractures among patients. Studies have reported …

Osteocytes are dynamic, bone matrix-remodeling cells that form an intricate network of
interconnected projections through the bone matrix, called the lacunar-canalicular system …

Irisin, released from exercised muscle, has been shown to have beneficial effects on
numerous tissues but its effects on bone are unclear. We found significant sex and genotype …

Patients with bone and muscle loss from prolonged disuse have higher risk of falls and
subsequent fragility fractures. In addition, fracture patients with continued disuse and/or …

This study's objective was to investigate how contractile strength loss associated with a
volumetric muscle loss (VML) injury affects the adjacent tibial bone structural and functional …

Fracture healing is a complex series of events that requires a local inflammatory reaction to
initiate the reparative process. This inflammatory reaction is important for stimulating the …

The molecular mechanism underlying the promotion of fracture healing by mechanical
stimuli remains unclear. The present study aimed to investigate the role of zinc finger protein …

Male patients often experience increased bone and muscle loss after traumatic fractures.
This study aims to compare the treatment outcomes of male and female patients with large …