[HTML][HTML] The quest for multiscale brain modeling

E D'Angelo, V Jirsa - Trends in neurosciences, 2022 - cell.com
Addressing the multiscale organization of the brain, which is fundamental to the dynamic
repertoire of the organ, remains challenging. In principle, it should be possible to model …

Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics

JM Shine, EJ Müller, B Munn, J Cabral, RJ Moran… - Nature …, 2021 - nature.com
Decades of neurobiological research have disclosed the diverse manners in which the
response properties of neurons are dynamically modulated to support adaptive cognitive …

A comprehensive neural simulation of slow-wave sleep and highly responsive wakefulness dynamics

JS Goldman, L Kusch, D Aquilue… - Frontiers in …, 2023 - frontiersin.org
Hallmarks of neural dynamics during healthy human brain states span spatial scales from
neuromodulators acting on microscopic ion channels to macroscopic changes in …

A multi-layer mean-field model of the cerebellum embedding microstructure and population-specific dynamics

RM Lorenzi, A Geminiani, Y Zerlaut… - PLOS Computational …, 2023 - journals.plos.org
Mean-field (MF) models are computational formalism used to summarize in a few statistical
parameters the salient biophysical properties of an inter-wired neuronal network. Their …

Exact mean-field models for spiking neural networks with adaptation

L Chen, SA Campbell - Journal of Computational Neuroscience, 2022 - Springer
Networks of spiking neurons with adaption have been shown to be able to reproduce a wide
range of neural activities, including the emergent population bursting and spike synchrony …

[HTML][HTML] From phenomenological to biophysical models of seizures

D Depannemaecker, A Ezzati, HE Wang, V Jirsa… - Neurobiology of …, 2023 - Elsevier
Epilepsy is a complex disease that requires various approaches for its study. This short
review discusses the contribution of theoretical and computational models. The review …

On the validity of neural mass models

N Deschle, J Ignacio Gossn, P Tewarie… - Frontiers in …, 2021 - frontiersin.org
Modeling the dynamics of neural masses is a common approach in the study of neural
populations. Various models have been proven useful to describe a plenitude of empirical …

High-density exploration of activity states in a multi-area brain model

D Aquilué-Llorens, JS Goldman, A Destexhe - Neuroinformatics, 2024 - Springer
To simulate whole brain dynamics with only a few equations, biophysical, mesoscopic
models of local neuron populations can be connected using empirical tractography data …

Comparison between an exact and a heuristic neural mass model with second-order synapses

P Clusella, E Köksal-Ersöz, J Garcia-Ojalvo… - Biological …, 2023 - Springer
Neural mass models (NMMs) are designed to reproduce the collective dynamics of neuronal
populations. A common framework for NMMs assumes heuristically that the output firing rate …

A model for the propagation of seizure activity in normal brain tissue

D Depannemaecker, M Carlu, J Bouté, A Destexhe - eneuro, 2022 - eneuro.org
Epilepsies are characterized by paroxysmal electrophysiological events and seizures, which
can propagate across the brain. One of the main unsolved questions in epilepsy is how …