Exploring the therapeutic potential of phytochemicals in Alzheimer's disease: Focus on polyphenols and monoterpenes

I Piccialli, V Tedeschi, L Caputo, S D'Errico… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a chronic, complex neurodegenerative disorder mainly
characterized by the irreversible loss of memory and cognitive functions. Different …

Current perspective in the discovery of anti-aging agents from natural products

AJ Ding, SQ Zheng, XB Huang, TK Xing, GS Wu… - Natural products and …, 2017 - Springer
Aging is a process characterized by accumulating degenerative damages, resulting in the
death of an organism ultimately. The main goal of aging research is to develop therapies …

[HTML][HTML] Monoterpenes modulating cytokines-A review

JSS Quintans, S Shanmugam, L Heimfarth… - Food and chemical …, 2019 - Elsevier
Inflammatory response can be driven by cytokine production and is a pivotal target in the
management of inflammatory diseases. Monoterpenes have shown that promising profile as …

RhoA/ROCK-2 pathway inhibition and tight junction protein upregulation by catalpol suppresses lipopolysaccaride-induced disruption of blood-brain barrier …

S Feng, L Zou, H Wang, R He, K Liu, H Zhu - Molecules, 2018 - mdpi.com
Lipopolysaccaride (LPS) directly or indirectly injures brain microvascular endothelial cells
(BMECs) and damages the intercellular tight junction that gives rise to altered blood-brain …

Multiple biological effects of an iridoid glucoside, catalpol, and its underlying molecular mechanisms

SK Bhattamisra, KH Yap, V Rao, H Choudhury - Biomolecules, 2019 - mdpi.com
Catalpol, an iridoid glucoside, is widely distributed in many plant families and is primarily
obtained from the root of Rehmannia glutinosa Libosch. Rehmannia glutinosa is a plant very …

Clinical efficacy, pharmacodynamic components, and molecular mechanisms of antiviral granules in the treatment of influenza: A systematic review

J Su, X Chen, Y Xie, M Li, Q Shang, D Zhang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance The Antiviral Granules (AG) are derived from the
classical famous prescription, which is composed of 9 traditional Chinese medicines …

Pharmacogenomics of Alzheimer's disease: Novel therapeutic strategies for drug development

R Cacabelos, P Cacabelos, C Torrellas… - … in Drug Discovery and …, 2014 - Springer
Alzheimer's disease (AD) is a major problem of health and disability, with a relevant
economic impact on our society. Despite important advances in pathogenesis, diagnosis …

Therapeutic potential of catalpol and geniposide in Alzheimer's and Parkinson's diseases: a snapshot of their underlying mechanisms

X Zhang, K Liu, M Shi, L Xie, M Deng, H Chen… - Brain Research Bulletin, 2021 - Elsevier
Rehmannia glutinosa, the fresh or dried root of Rehmannia glutinosa (Gaertn.) Libosch. ex
Fisch. & Mey., and Gardenia, the fruit of Gardenia jasminoides Ellis from Rubiaceae, both …

Piperine regulates glycogen synthase kinase-3β-related signaling and attenuates cognitive decline in D-galactose-induced aging mouse model

C Wang, Z Cai, W Wang, M Wei, X Si, Y Shang… - The Journal of nutritional …, 2020 - Elsevier
Aging-related cholinergic dysfunction, extensive neuroinflammation and oxidative stress in
brain are predominant pathogenic factors for dementia. In the present study, we aimed to …

Antiaging effects of bioactive molecules isolated from plants and fungi

J Martel, DM Ojcius, YF Ko, CJ Chang… - Medicinal Research …, 2019 - Wiley Online Library
Aging is influenced by many lifestyle choices that are under human control, including
nutrition and exercise. The most effective known antiaging intervention consists of calorie …