Tissue resident memory T (TRM) cells reside in peripheral, non-lymphoid tissues such as
the skin, where they act as alarm-sensor cells or cytotoxic cells. Physiologically, skin TRM …

The skin is the largest organ of the body. The establishment of immunological memory in the
skin is a crucial component of the adaptive immune response. Once naive T cells are …

Tissue-resident memory (TRM) CD8+ T cells are largely derived from recently activated
effector T cells, but the mechanisms that control the extent of TRM differentiation within …

Regulatory T cells (Tregs) are required to establish immune tolerance to commensal
microbes. Tregs accumulate abruptly in the skin during a defined window of postnatal tissue …

Background In previous human skin single-cell data, inflammatory cells constituted only a
small fraction of the overall cell population, such that functional subsets were difficult to …

Immune checkpoint blockade (ICB) enhances T cell responses against cancer, leading to
long-term survival in a fraction of patients. CD8+ T cell differentiation in response to chronic …

An increasing body of evidence emphasizes the role of tissue-resident memory T cells (T
RM) in the defense against recurring pathogens and malignant neoplasms. However, little is …

On single-cell RNA-sequencing data, we consider the problem of assigning cells to known
cell types, assuming that the identities of cell-type-specific marker genes are given but their …

Infection or inflammation of the skin recruits effector CD8+ T cells that enter the epidermis
and form populations of long-lived tissue-resident memory T (T RM) cells. These skin T RM …

Regulatory T cells (Tregs) offer new immunotherapeutic options to control undesired
immune reactions, such as those in transplant rejection and autoimmunity. In addition, tissue …