How vascular smooth muscle cell phenotype switching contributes to vascular disease

G Cao, X Xuan, J Hu, R Zhang, H Jin… - Cell Communication and …, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …

Vascular smooth muscle cells in atherosclerosis: time for a re-assessment

MOJ Grootaert, MR Bennett - Cardiovascular research, 2021 - academic.oup.com
Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …

Six shades of vascular smooth muscle cells illuminated by KLF4 (Krüppel-Like Factor 4)

C Yap, A Mieremet, CJM de Vries, D Micha… - … , and vascular biology, 2021 - Am Heart Assoc
Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels
forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to …

Fate and state of vascular smooth muscle cells in atherosclerosis

JM Miano, EA Fisher, MW Majesky - Circulation, 2021 - Am Heart Assoc
Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic
modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing …

Vascular smooth muscle cells and arterial stiffening: relevance in development, aging, and disease

P Lacolley, V Regnault, P Segers… - Physiological …, 2017 - journals.physiology.org
The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Smooth muscle cells contribute the majority of foam cells in ApoE (Apolipoprotein E)-deficient mouse atherosclerosis

Y Wang, JA Dubland, S Allahverdian… - … , and vascular biology, 2019 - Am Heart Assoc
Objective—Smooth muscle cells (SMCs) are the most abundant cells in human
atherosclerotic lesions and are suggested to contribute at least 50% of atheroma foam cells …

Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease

EM Maguire, SWA Pearce, Q Xiao - Vascular Pharmacology, 2019 - Elsevier
During atherosclerosis, the gradual accumulation of lipids into the subendothelial space of
damaged arteries results in several lipid modification processes followed by macrophage …

Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels

L Dobnikar, AL Taylor, J Chappell, P Oldach… - Nature …, 2018 - nature.com
Vascular smooth muscle cells (VSMCs) show pronounced heterogeneity across and within
vascular beds, with direct implications for their function in injury response and …

Smooth muscle cell phenotypic diversity: At the crossroads of lineage tracing and single-cell transcriptomics

M Liu, D Gomez - Arteriosclerosis, thrombosis, and vascular …, 2019 - Am Heart Assoc
Vascular smooth muscle cells (SMC) play a critical role in controlling blood pressure and
blood distribution, as well as maintaining the structural integrity of the blood vessel. SMC …

Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation

J Totoń-Żurańska, TP Mikolajczyk, B Saju… - Clinical …, 2024 - portlandpress.com
Optimal vascular structure and function are essential for maintaining the physiological
functions of the cardiovascular system. Vascular remodelling involves changes in vessel …