Colorectal cancer (CRC) is the third leading cause of cancer death in the world, and its
incidence is rising in developing countries. Treatment with 5-Fluorouracil (5-FU) is known to …

Our genome is constantly exposed to endogenous and exogenous sources of DNA damage
resulting in various alterations of the genetic code. DNA double-strand breaks (DSBs) are …

The error-free and efficient repair of DNA double-stranded breaks (DSBs) is extremely
important for cell survival. RNA has been implicated in the resolution of DNA damage but the …

Microprocessor initiates the processing of microRNAs (miRNAs) from the hairpin regions of
primary transcripts (pri-miRNAs). Pri-miRNAs often contain multiple miRNA hairpins, and …

MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical
for downstream processing and mature miRNA target specificity. To understand how pri …

ABSTRACT DROSHA is the catalytic subunit of the Microprocessor complex, which initiates
microRNA (miRNA) maturation in the nucleus by recognizing and cleaving hairpin …

Alzheimer's disease (AD) is a neurodegenerative disease with no effective cure that attacks
the brain's cells resulting in memory loss and changes in behavior and language skills …

Mutations in the Fused in Sarcoma (FUS) gene cause the familial and progressive form of
amyotrophic lateral sclerosis (ALS). FUS is a nuclear RNA-binding protein involved in RNA …

The co-delivery of microRNAs (miRNAs) and protein-coding RNA presents an opportunity
for a combined approach to gene expression and gene regulation for therapeutic …

Single-stranded microRNAs (miRNAs) regulate gene expression by triggering mRNA
degradation and/or inhibiting mRNA translation. miRNAs play important roles in various …