Infection as a stroke risk factor and determinant of outcome after stroke

MSV Elkind, AK Boehme, CJ Smith, A Meisel… - Stroke, 2020 - Am Heart Assoc
Understanding the relationship between infection and stroke has taken on new urgency in
the era of the coronavirus disease 2019 (COVID-19) pandemic. This association is not a …

Immunodepression, infections, and functional outcome in ischemic stroke

WF Westendorp, C Dames, PJ Nederkoorn, A Meisel - Stroke, 2022 - Am Heart Assoc
Stroke remains one of the main causes of mortality and morbidity worldwide. Immediately
after stroke, a neuroinflammatory process starts in the brain, triggering a systemic …

Stroke-associated pneumonia: major advances and obstacles

Y Hannawi, B Hannawi, CPV Rao, JI Suarez… - Cerebrovascular …, 2013 - karger.com
Background: Stroke-associated pneumonia (SAP) has been implicated in the morbidity,
mortality and increased medical cost after acute ischemic stroke. The annual cost of SAP …

Inflammatory responses in brain ischemia

M Kawabori, M A. Yenari - Current medicinal chemistry, 2015 - benthamdirect.com
Brain infarction causes tissue death by ischemia due to occlusion of the cerebral vessels
and recent work has shown that post stroke inflammation contributes significantly to the …

Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets

JY Kim, M Kawabori, MA Yenari - Current medicinal chemistry, 2014 - ingentaconnect.com
Stroke is a frequent cause of long-term disability and death worldwide. Ischemic stroke is
more commonly encountered compared to hemorrhagic stroke, and leads to tissue death by …

Stroke-induced immunodepression: experimental evidence and clinical relevance

U Dirnagl, J Klehmet, JS Braun, H Harms, C Meisel… - Stroke, 2007 - Am Heart Assoc
Stroke affects the normally well-balanced interplay of the 2 supersystems: the nervous and
the immune system. Recent research elucidated some of the involved signals and …

Acute ischaemic stroke and infection: recent and emerging concepts

HCA Emsley, SJ Hopkins - The Lancet Neurology, 2008 - thelancet.com
The relation between acute ischaemic stroke and infection is complex. Infection appears to
be an important trigger that precedes up to a third of ischaemic strokes and can bring about …

Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level

B Brommer, O Engel, MA Kopp, R Watzlawick, S Müller… - Brain, 2016 - academic.oup.com
Pneumonia is the leading cause of death after acute spinal cord injury and is associated
with poor neurological outcome. In contrast to the current understanding, attributing …

Ischemia, immunosuppression and infection—tackling the predicaments of post-stroke complications

R Shim, CHY Wong - International journal of molecular sciences, 2016 - mdpi.com
The incidence of stroke has risen over the past decade and will continue to be one of the
leading causes of death and disability worldwide. While a large portion of immediate death …

Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice

A Alawieh, EF Langley, S Tomlinson - Science translational medicine, 2018 - science.org
Ischemic stroke results from the interruption of blood flow to the brain resulting in long-term
motor and cognitive neurological deficits, and it is a leading cause of death and disability …