Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target

KA Abrahams, GS Besra - Parasitology, 2018 - cambridge.org
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is recognized
as a global health emergency as promoted by the World Health Organization. Over 1 million …

Vitamin in the crosshairs: targeting pantothenate and coenzyme a biosynthesis for new antituberculosis agents

HS Butman, TJ Kotzé, CS Dowd… - Frontiers in Cellular and …, 2020 - frontiersin.org
Despite decades of dedicated research, there remains a dire need for new drugs against
tuberculosis (TB). Current therapies are generations old and problematic. Resistance to …

Design and synthesis of isoniazid-based pyrazolines as potential inhibitors of Mycobacterium tuberculosis with promising radical scavenging action: in-vitro and in …

J Rasgania, R Gavadia, M Varma-Basil… - Journal of Molecular …, 2024 - Elsevier
In view of the devastating tuberculosis infections and emerging resistance against available
drugs, novel 5-phenyl-3-(thiophen-2-yl)-4, 5-dihydro-1H-pyrazol-1-yl)(pyridin-4-yl) …

Terminalia laxiflora and Terminalia brownii contain a broad spectrum of antimycobacterial compounds including ellagitannins, ellagic acid derivatives, triterpenes, fatty …

EYA Salih, R Julkunen-Tiitto, AM Lampi… - Journal of …, 2018 - Elsevier
Abstract Ethnopharmacological relevance Terminalia laxiflora Engl. & Diels,(Sudanese
Arabic name: Darout الدروت) and Terminalia brownii Fresen (Sudanese Arabic name: Alshaf …

Synthesis of indole-functionalized isoniazid conjugates with potent antimycobacterial and antioxidant efficacy

R Gavadia, J Rasgania, N Sahu… - Future Medicinal …, 2024 - Taylor & Francis
Aim: Developing potent medicinal alternates for tuberculosis (TB) is highly desirable due to
the advent of drug-resistant lethal TB strains. Methods & results: Novel indole-isoniazid …

Solubilized ubiquinol for preserving corneal function

YW Naguib, S Saha, JM Skeie, T Acri, K Ebeid… - Biomaterials, 2021 - Elsevier
Defective cellular metabolism, impaired mitochondrial function, and increased cell death are
major problems that adversely affect donor tissues during hypothermic preservation prior to …

Potential Anti-Tuberculosis Activity of the Extracts and Their Active Components of Anogeissus leiocarpa (DC.) Guill. and Perr. with Special Emphasis on Polyphenols

EYA Salih, R Julkunen-Tiitto, O Luukkanen, M Sipi… - Antibiotics, 2020 - mdpi.com
In Sudanese traditional medicine, decoctions of the stem bark of Anogeissus leiocarpa are
used for the treatment of tuberculosis (TB). However, this plant has not been investigated …

In Silico Approach: Anti-Tuberculosis Activity of Caespitate in the H37Rv Strain

A Moreno-Ceballos, NA Caballero, ME Castro… - Current Issues in …, 2024 - mdpi.com
Tuberculosis is a highly lethal bacterial disease worldwide caused by Mycobacterium
tuberculosis (Mtb). Caespitate is a phytochemical isolated from Helichrysum caespititium, a …

Structural basis for inhibition of enoyl-[acyl carrier protein] reductase (InhA) from Mycobacterium tuberculosis

MB de Ávila, G Bitencourt-Ferreira… - Current Medicinal …, 2020 - ingentaconnect.com
Background: The enzyme trans-enoyl-[acyl carrier protein] reductase (InhA) is a central
protein for the development of antitubercular drugs. This enzyme is the target for the pro …

Dietary pattern characterized by a balanced diet rich in high-quality protein intake is associated with mild initial clinical manifestations in tuberculosis

X Li, Z Zhong, Y Liu, G Gong, Y Zhang, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Background The relationship between a single food or nutrient and pulmonary tuberculosis
(TB) has been explored in many studies; however, the relationship between dietary patterns …