Genome editing is the modification of genomic DNA at a specific target site in a wide variety
of cell types and organisms, including insertion, deletion and replacement of DNA, resulting …

Animal models of human diseases play a critical role in medical research. Pigs are
anatomically and physiologically more like humans than are small rodents such as mice …

CRISPR/Cas9 technology has become the most examined gene editing technology in
recent years due to its simple design, yet low cost, high efficiency, and simple operation …

Accelerated development of novel CRISPR/Cas9-based genome editing techniques
provides a feasible approach to introduce a variety of precise modifications in the …

Pigs serve as an important agricultural resource and animal model in biomedical studies.
Efficient and precise modification of pig genome by using recently developed gene editing …

Gastrointestinal cancer (GI) is one of the most serious and health-threatening diseases
worldwide. Many countries have encountered an escalating prevalence of shock. Therefore …

Genetically modified animals, especially rodents, are widely used in biomedical research.
However, non-rodent models are required for efficient translational medicine and preclinical …

The foundation for investigating the mechanisms of human diseases is the establishment of
animal models, which are also widely used in agricultural industry, pharmaceutical …

Diabetes mellitus is a chronic disease with accompanying severe complications. Various
animal models, mostly rodents due to availability of genetically modified lines, have been …

The CRISPR/Cas9 system enables a versatile set of genomes editing and genetic-based
disease modeling tools due to its high specificity, efficiency, and accessible design and …