Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

Adenosine signals through four distinct G protein-coupled receptors that are located at
various synapses, cell types and brain areas. Through them, adenosine regulates …

Alzheimer's disease (AD) is the most prevalent kind of dementia with roughly 135 million
cases expected in the world by 2050. Unfortunately, current medications for the treatment of …

About 10 million new cases of dementia develop worldwide each year, of which up to 70%
are attributable to Alzheimer's disease (AD). In addition to the widely known symptoms of …

The conception of coffee consumption has undergone a profound modification, evolving
from a noxious habit into a safe lifestyle actually preserving human health. The last 20 years …

Adenosine receptors mainly control synaptic function, and excessive activation of adenosine
receptors may worsen the onset of many neurological disorders. Accordingly, the regular …

Caffeine is the world's most popular stimulant and psychoactive substance. Given the
ubiquitous use of caffeine, it is crucial for us to comprehend how our body interacts with …

Multitarget drugs based on a hybrid dopamine–xanthine core were designed as potential
drug candidates for the treatment of neurodegenerative diseases. Monoamine oxidase B …

Paraxanthine (PXN) is the main metabolite of caffeine (CAF). PXN supplementation has
been shown to increase measures of cognition, memory, reasoning, response time, and …

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of
corticospinal tract motor neurons. Previous studies showed that adenosine-mediated …