Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Collagen is one of the most useful biopolymers because of its low immunogenicity and
biocompatibility. The biomedical potential of natural collagen is limited by its poor …

Clear cell Renal Cell Carcinoma (ccRCC) is the most common and metastatic urological
cancer. Molecular players of ccRCC progression and metastasis are not completely known …

The five genes of the lysyl oxidase family encode enzymes that covalently cross-link
components of the extracellular matrix, such as various types of collagen and elastin, and …

Simple Summary To improve efficacy of solid cancer treatment, efforts have shifted towards
targeting both the cancer cells and the surrounding tumour tissue they grow in. The lysyl …

The adipocyte-like morphology of clear cell renal cell carcinoma (ccRCC) cells results from a
grade-dependent neutral lipid accumulation; however, the molecular mechanism and role in …

The lysyl oxidase (LOX) family is comprised of LOX and four LOX-like proteins (LOXL1,
LOXL2, LOXL3, and LOXL4), and mainly functions in the remodeling of extracellular matrix …

Clear cell renal cell carcinoma (ccRCC) has a poor prognosis despite novel biological
targeted therapies. Tumor aggressiveness and poor survival may correlate with tumor grade …

Most tumors develop abnormal fibrotic regions consisting of fibroblasts, immune cells, and a
dense extracellular matrix (ECM) immersed in a viscous interstitial fluid, and an abundant …

The extracellular matrix (ECM) is a key acellular structure in constant remodeling to provide
tissue cohesion and rigidity. Deregulation of the balance between matrix deposition …