Transcription regulation networks control the expression of genes. The transcription
networks of well-studied microorganisms appear to be made up of a small set of recurring …

Network medicine is an emerging area of research dealing with molecular and genetic
interactions, network biomarkers of disease, and therapeutic target discovery. Large-scale …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

It has been a long-standing goal in systems biology to find relations between the topological
properties and functional features of protein networks. However, most of the focus in network …

Background Usually the reference genes used in gene expression analysis have been
chosen for their known or suspected housekeeping roles, however the variation observed in …

The regulatory interactions between transcription factors and their target genes can be
conceptualised as a directed graph. At a global level, these regulatory networks display a …

Gene co‐expression analysis has emerged in the past 5 years as a powerful tool for gene
function prediction. In essence, co‐expression analysis asks the question 'what are the …

The execution of complex biological processes requires the precise interaction and
regulation of thousands of molecules. Systematic approaches to study large numbers of …

Motivation: Signaling pathways are dynamic events that take place over a given period of
time. In order to identify these pathways, expression data over time are required. Dynamic …

We are beginning to elucidate transcriptional regulatory networks on a large scale and to
understand some of the structural principles of these networks,, but the evolutionary …