The emerging role of microRNAs in polyglutamine diseases
X Dong, S Cong - Frontiers in Molecular Neuroscience, 2019 - frontiersin.org
MicroRNAs (miRNAs) are small non-coding molecules that regulate a large amount of post-
transcriptional repressor genes by recognizing semi-complementary target sequences that …
transcriptional repressor genes by recognizing semi-complementary target sequences that …
Comprehensive in silico analysis and molecular dynamics of the superoxide dismutase 1 (SOD1) variants related to amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disorder, with a
significant social and economic burden. ALS remains incurable, and the only drugs …
significant social and economic burden. ALS remains incurable, and the only drugs …
Studies on the interaction of 2, 4-dibromophenol with human hemoglobin using multi-spectroscopic, molecular docking and molecular dynamics techniques
Dibromophenol (DBP) has several industrial applications, including as a wood preservative
and flame retardant. This study investigated the interaction between DBP and human …
and flame retardant. This study investigated the interaction between DBP and human …
Topological and system-level protein interaction network (PIN) analyses to deduce molecular mechanism of curcumin
Curcumin is an important bioactive component of turmeric and also one of the important
natural products, which has been investigated extensively. The precise mode of action of …
natural products, which has been investigated extensively. The precise mode of action of …
Repurposing drug molecule against SARS-Cov-2 (COVID-19) through molecular docking and dynamics: a quick approach to pick FDA-approved drugs
N Farhat, AU Khan - Journal of Molecular Modeling, 2021 - Springer
A novel coronavirus known as severe acute respiratory syndrome is rapidly spreading
worldwide. The international health authorities are putting all their efforts on quick diagnosis …
worldwide. The international health authorities are putting all their efforts on quick diagnosis …
Broad-spectrum inhibitors against class A, B, and C type β-lactamases to block the hydrolysis against antibiotics: kinetics and structural characterization
The emergence of antibiotic resistance has led to a global crisis for the physician to handle
infection control issues. All antibiotics, including colistin, have lost efficiency against …
infection control issues. All antibiotics, including colistin, have lost efficiency against …
Inhibitors against New Delhi metallo-betalactamase-1 (NDM-1) and its variants endemic in Indian settings along with the laboratory functional gain mutant of NDM-1
N Farhat, AU Khan - European Journal of Clinical Microbiology & …, 2024 - Springer
Purpose The emergence of NDM-1 producing bacteria has become common in both
hospital and community settings, but no inhibitor has yet been available for clinical …
hospital and community settings, but no inhibitor has yet been available for clinical …
Identification of new BACE1 inhibitors for treating Alzheimer's disease
P Kushwaha, V Singh, P Somvanshi… - Journal of Molecular …, 2021 - Springer
Alzheimer's disease (AD) is a type of brain disorder, wherein a person experiences gradual
memory loss, state of confusion, hallucination, agitation, and personality change. AD is …
memory loss, state of confusion, hallucination, agitation, and personality change. AD is …
Repurposing FDA approved drug molecules against ABC classes of β-lactamases: a computational biology and molecular dynamics simulations study
N Farhat, AU Khan - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
Abstract β-lactamase are the main resistance factor for β-lactam antibiotics in Gram-negative
bacteria. Since β-lactam antibiotics are being utilised as an antimicrobial agents extensively …
bacteria. Since β-lactam antibiotics are being utilised as an antimicrobial agents extensively …
Molecular docking, dynamics, and pharmacology studies on bexarotene as an agonist of ligand‐activated transcription factors, retinoid X receptors
Retinoid X receptors (RXRs) belong to the nuclear receptor superfamily, and upon ligand
activation, these receptors control gene transcription via either homodimerization with …
activation, these receptors control gene transcription via either homodimerization with …