Since their inception, genome-wide association studies (GWAS) have identified more than a
hundred thousand single nucleotide polymorphism (SNP) loci that are associated with …

Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …

Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …

The resources generated by the GTEx consortium offer unprecedented opportunities to
advance our understanding of the biology of human diseases. Here, we present an in-depth …

Most studies of gene expression in the brains of individuals with schizophrenia have
focused on cortical regions, but subcortical nuclei such as the striatum are prominently …

Addressing the challenges of climate change and durum wheat production is becoming an
important driver for food and nutrition security in the Mediterranean area, where are located …

Cotton is an important economic crop, and many loci for important traits have been
identified, but it remains challenging and time-consuming to identify candidate or causal …

Colocalization analysis has emerged as a powerful tool to uncover the overlapping of causal
variants responsible for both molecular and complex disease phenotypes. The findings from …

Background The pathophysiological causes of kidney disease are not fully understood. Here
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …

Discovering novel uses for existing drugs, through drug repurposing, can reduce the time,
costs, and risk of failure associated with new drug development. However, prioritizing drug …