1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

Skin cancer is the most commonly diagnosed cancer worldwide. Understanding the natural
history of skin cancer provides the framework for the creation of prevention and control …

Vitamins with antioxidant characteristics have been shown as potential chemopreventive
agents because of their roles in quenching free radicals and decreasing oxidative damage …

Observational studies, randomized controlled trials (RCTs), and Mendelian randomization
(MR) studies have yielded inconsistent results on the associations of vitamin D …

Skin is the outermost covering of the human body and at the same time the largest organ
comprising 15% of body weight and 2 m2 surface area. Skin plays a key role as a barrier …

There has been substantial enthusiasm recently regarding the potential role of vitamin D in
the primary and secondary prevention of cancer. Laboratory studies demonstrate a range of …

Melanoma, a tumor arising from a melanocyte (the cell responsible for producing pigment),
continues to carry the potential to be a deadly disease. In the United States, 91,320 new …

Sun exposure is a major environmental risk factor for skin cancers and is also an important
source of vitamin D. However, while experimental evidence suggests that vitamin D may …

Vitamin D is the sunshine vitamin. During exposure to sunlight, 7-dehydrocholesterol in the
skin absorbs ultraviolet B (UVB) radiation converting it to previtamin D3. Previtamin D3 …

Non-melanoma skin cancer (NMSC) is the most common form of cancer in the Caucasian
population. Among NMSC types, basal cell carcinoma (BCC) has the highest incidence and …