Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing
transcription factor that regulates diverse cellular processes such as cell growth …

Follicle-stimulating hormone signaling is essential for the initiation and early stages of
spermatogenesis. Follicle-stimulating hormone receptor is exclusively expressed in Sertoli …

The etiology of aortic aneurysms is poorly understood, but it is associated with
atherosclerosis, hypercholesterolemia, and abnormal transforming growth factor β (TGF-β) …

The transcription factor Kruppel-like factor 4 (KLF4) has the ability, along with other factors,
to reprogram somatic cells into induced pluripotent stem (iPS) cells. Here, we determined …

Although glomerular endothelial dysfunction is well recognized as contributing to the
pathogenesis of diabetic kidney disease (DKD), the molecular pathways contributing to DKD …

Agouti-related peptide (AgRP) neurons of the hypothalamus play a key role in regulating
food intake and body weight, by releasing three different orexigenic molecules: AgRP; …

There is a paucity of information about potential molecular brakes on the activation of
fibroblasts that drive tissue fibrosis. The transcription factor Krüppel-like factor 4 (KLF4) is …

Sertoli cells (Sc) are the sole target of follicle-stimulating hormone (FSH) in the testis and
attain functional maturation post-birth to significantly augment germ cell (Gc) division and …

Abstract Kruppel-like factor 4 (KLF4) is a key transcriptional regulator of cell differentiation
and proliferation and an altered expression of KLF4 has been reported in a number of …

The process of testis development in mammals is accompanied by the proliferation and
maturation of Sertoli, Leydig and germ cells. Spermatogenesis depends on hormone …