Cocrystals by design: a rational coformer selection approach for tackling the API problems

M Singh, H Barua, VGSS Jyothi, MR Dhondale… - Pharmaceutics, 2023 - mdpi.com
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …

Crystalline multicomponent solids: An alternative for addressing the hygroscopicity issue in pharmaceutical materials

TS Thakur, R Thakuria - Crystal Growth & Design, 2020 - ACS Publications
The ambient humidity varies with seasons and geographical altitude across the regions. A
change in relative humidity during processing, storage, and transportation can cause …

Green and efficient delivery of pesticides throughout their life cycle via cooperative solid and solution self-assembly

Y Xiao, C Wu, S Feng, M Chen, H Cao, K Chen… - Chemical Engineering …, 2023 - Elsevier
Addressing the economic and environmental challenges posed by non-target losses
throughout the pesticide life cycle necessitates a simple, yet effective strategy. In this work, a …

Progress on cocrystallization of poorly soluble NME's in the last decade

P Roy, A Ghosh - CrystEngComm, 2020 - pubs.rsc.org
For tailoring the physicochemical properties of active pharmaceutical ingredients,
cocrystallization has been an exciting field of interest to the researchers. As in recent years …

Hydrophilic Cocrystals with Water Switched Luminescence

L Gao, GV Baryshnikov, A Ali, A Kuklin… - Angewandte Chemie …, 2024 - Wiley Online Library
Utilizing water molecules to regulate the luminescence properties of solid materials is highly
challenging. Herein, we develop a strategy to produce water‐triggered luminescence …

Can we identify the salt–cocrystal continuum state using XPS?

S Tothadi, TR Shaikh, S Gupta, R Dandela… - Crystal Growth & …, 2021 - ACS Publications
X-ray photoelectron spectroscopy (XPS) is used to understand the nature of acid–base
crystalline solids, to know whether the product is a salt (proton transfer, O–··· H–N+) or a …

Surface characterization of pharmaceutical solids

A Kaur, DP Kale, AK Bansal - TrAC Trends in Analytical Chemistry, 2021 - Elsevier
Surface properties alter solid-solid and solid-liquid interfacial interactions that profoundly
impact manufacturability, processability, dissolution kinetics and stability of pharmaceutical …

[HTML][HTML] Preparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs

Y Meng, F Tan, J Yao, Y Cui, Y Feng, Z Li… - International Journal of …, 2022 - Elsevier
Rivaroxaban (RIV) is a direct Factor Xa inhibitor anticoagulant, but the oral bioavailability of
RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to …

Measurement and correlation of solubility of rivaroxaban in dichloromethane and primary alcohol binary solvent mixtures at different temperatures

JS Jeong, ES Ha, H Park, SK Lee, JS Kim… - Journal of Molecular …, 2022 - Elsevier
The solubility of rivaroxaban in different solvent mixtures consisting of dichloromethane and
primary alcohols, including methanol, ethanol, n-propanol, and n-butanol, was evaluated …

Surface-Induced Thermal Decomposition of Energetic Cocrystal CL-20/MTNP Based on In Situ Morphology and Crystal Structure Characterizations

Y Xiao, H Huang, X Zhao, P Zou, L Wei… - Crystal Growth & …, 2023 - ACS Publications
Surface structures and properties are particularly important for various materials, as they can
transport to the bulk properties in special cases and affect the applications of materials …