Background The efficacy of selective serotonin reuptake inhibitors (SSRIs) in the treatment
of acute COVID-19 is still under investigation, with conflicting results reported from …

Mounting evidence links obesity, metabolic dysfunction, mood, and cognition. Compromised
metabolic health and psychological functioning worsen clinical outcomes, diminish quality of …

Importance The ELEKT-D: Electroconvulsive Therapy (ECT) vs Ketamine in Patients With
Treatment Resistant Depression (TRD)(ELEKT-D) trial demonstrated noninferiority of …

Major depressive disorder (MDD) is the leading cause of disability worldwide, yet treatment
selection still proceeds via “trial and error”. Given the varied presentation of MDD and …

Background Individuals with major depressive disorder (MDD) are at higher risk for obesity.
In turn, weight gain is a predisposing factor for depression. Although clinical data are sparse …

Background Exercise promotes immunometabolic health and is increasingly recognized as
an effective depression treatment. Exercise may be beneficial for patients with …

Background Major depressive disorder (MDD) has a significant impact on global burden of
disease. Complications in clinical management can occur when response to …

Depression has several negative effects on emotion as well as learning and memory
abilities. Previous studies showed that depression could exacerbate inflammation, which in …

BackgroundProfiling patients on a proposed 'immunometabolic depression'(IMD) dimension,
described as a cluster of atypical depressive symptoms related to energy regulation and …

Objective: Previous prediction models for electroconvulsive therapy (ECT) responses have
predominantly been based on neuroimaging data, which has precluded widespread …