In a world in which life expectancy is increasing, understanding and promoting healthy
aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade …

Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation,
mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced …

Background Sepsis and inflammation can cause intensive care unit‐acquired weakness
(ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 …

Background Septic cardiomyopathy worsens the prognosis of critically ill patients. Clinical
data suggest that interleukin‐1β (IL‐1β), activated by the NLRP3 inflammasome …

The majority of critically ill intensive care unit (ICU) patients with severe sepsis develop ICU-
acquired weakness (ICUAW) characterized by loss of muscle mass, reduction in myofiber …

Although denervated muscle atrophy is common, the underlying molecular mechanism
remains unelucidated. We have previously found that oxidative stress and inflammatory …

Skeletal muscle loss is a detrimental side-effect of numerous chronic diseases that
dramatically increases mortality and morbidity. The alteration of protein homeostasis is …

The landscape of cancer cachexia in advanced non-small cell lung cancer: a narrative review
- PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage …

Sepsis‐induced muscle atrophy often increases morbidity and mortality in intensive care unit
(ICU) patients, yet neither therapeutic target nor optimal animal model is available for this …

Sepsis is caused by the invasion of pathogenic microorganisms, which can lead to
excessive expression of toll-like receptors (TLRs) in cells and uncontrollable amplification of …