Obesity and diabetes now considered global epidemics. The prevalence rates of diabetes
are increasing in parallel with the rates of obesity and the strong connection between these …

Abstract Purpose of Review This review summarizes the alterations in the β-cell observed in
type 2 diabetes (T2D), focusing on changes in β-cell identity and mass and changes …

Type 1 diabetes is characterized by the destruction of pancreatic β cells, and generating
new insulin-producing cells from other cell types is a major aim of regenerative medicine …

Human pluripotent stem cells differentiated to insulin-secreting β cells (SC-β cells) in islet
organoids could provide an unlimited cell source for diabetes cell replacement therapy …

Scope The present study aims to assess the antidiabetic effect of Lactobacillus paracasei
strain NL41 and its potential mechanisms in rats with type 2 diabetes mellitus (T2DM) …

In contrast to mice, zebrafish have an exceptional yet elusive ability to replenish lost β cells
in adulthood. Understanding this framework would provide mechanistic insights for β cell …

The human endocrine pancreas consists of multiple cell types and plays a critical role in
glucose homeostasis. Here, we apply mass cytometry technology to measure all major islet …

Background Diabetes mellitus is characterized by loss or dysfunction of insulin-producing β-
cells in the pancreas, resulting in failure of blood glucose regulation and devastating …

Enteroendocrine cells (EECs) are specialized sensory cells in the intestinal epithelium that
sense and transduce nutrient information. Consumption of dietary fat contributes to …

Damage to regional cerebrovascular networks and neuronal tissues occurs during acute
cerebrovascular diseases, such as ischemic stroke. The promotion of vascular regeneration …