Structural and chemical biology of terpenoid cyclases
DW Christianson - Chemical reviews, 2017 - ACS Publications
The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …
Decoding catalysis by terpene synthases
JN Whitehead, NGH Leferink, LO Johannissen… - ACS …, 2023 - ACS Publications
The review by Christianson, published in 2017 on the twentieth anniversary of the
emergence of the field, summarizes the foundational discoveries and key advances in …
emergence of the field, summarizes the foundational discoveries and key advances in …
Terpene synthases as metabolic gatekeepers in the evolution of plant terpenoid chemical diversity
PS Karunanithi, P Zerbe - Frontiers in plant science, 2019 - frontiersin.org
Terpenoids comprise tens of thousands of small molecule natural products that are widely
distributed across all domains of life. Plants produce by far the largest array of terpenoids …
distributed across all domains of life. Plants produce by far the largest array of terpenoids …
Enzyme function initiative-enzyme similarity tool (EFI-EST): a web tool for generating protein sequence similarity networks
JA Gerlt, JT Bouvier, DB Davidson, HJ Imker… - … Et Biophysica Acta (BBA …, 2015 - Elsevier
Abstract The Enzyme Function Initiative, an NIH/NIGMS-supported Large-Scale
Collaborative Project (EFI; U54GM093342; http://enzymefunction. org/), is focused on …
Collaborative Project (EFI; U54GM093342; http://enzymefunction. org/), is focused on …
Genomic enzymology: web tools for leveraging protein family sequence–function space and genome context to discover novel functions
JA Gerlt - Biochemistry, 2017 - ACS Publications
The exponentially increasing number of protein and nucleic acid sequences provides
opportunities to discover novel enzymes, metabolic pathways, and metabolites/natural …
opportunities to discover novel enzymes, metabolic pathways, and metabolites/natural …
Revealing unexplored sequence-function space using sequence similarity networks
The rapidly expanding number of protein sequences found in public databases can improve
our understanding of how protein functions evolve. However, our current knowledge of …
our understanding of how protein functions evolve. However, our current knowledge of …
Enzymatic control of product distribution in terpene synthases: insights from multiscale simulations
In this opinion, we review some recent work on terpene biosynthesis using multiscale
simulation approaches, with special focus on contributions from our group. Terpene …
simulation approaches, with special focus on contributions from our group. Terpene …
The impression of a nonexisting catalytic effect: the role of CotB2 in guiding the complex biosynthesis of cyclooctat-9-en-7-ol
K Raz, R Driller, N Dimos, M Ringel… - Journal of the …, 2020 - ACS Publications
Terpene synthases generate terpenes employing diversified carbocation chemistry,
including highly specific ring formations, proton and hydride transfers, and methyl as well as …
including highly specific ring formations, proton and hydride transfers, and methyl as well as …
Enzydock: Protein–ligand docking of multiple reactive states along a reaction coordinate in enzymes
Enzymes play a pivotal role in all biological systems. These biomachines are the most
effective catalysts known, dramatically enhancing the rate of reactions by more than 10 …
effective catalysts known, dramatically enhancing the rate of reactions by more than 10 …
Mechanistically informed predictions of binding modes for carbocation intermediates of a sesquiterpene synthase reaction
Sesquiterpenoids comprise a class of terpenoid natural products with thousands of
compounds that are highly diverse in structure, generally containing a polycyclic carbon …
compounds that are highly diverse in structure, generally containing a polycyclic carbon …