Structural and chemical biology of terpenoid cyclases

DW Christianson - Chemical reviews, 2017 - ACS Publications
The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …

Sesquiterpene synthases: passive catalysts or active players?

DJ Miller, RK Allemann - Natural Product Reports, 2012 - pubs.rsc.org
Covering: up to July 2011 Sesquiterpene synthases catalyse the metal dependent turnover
of farnesyl diphosphate to generate a class of natural products characterised by an …

Suppression of terpenoid synthesis in plants by a virus promotes its mutualism with vectors

JB Luan, DM Yao, T Zhang, LL Walling, M Yang… - Ecology …, 2013 - Wiley Online Library
Vectors often perform better on plants infected with pathogens, and this promotes the spread
of pathogens. However, few studies have examined how plant defensive compounds …

Identification of sesquiterpene synthases from the Basidiomycota Coniophora puteana for the efficient and highly selective β-copaene and cubebol production in E …

W Mischko, M Hirte, M Fuchs, N Mehlmer… - Microbial cell …, 2018 - Springer
Background Terpenes are an important and extremely versatile class of secondary
metabolites that are commercially used in the pharmaceutical, food and cosmetics sectors …

Mushroom hunting by using bioinformatics: application of a predictive framework facilitates the selective identification of sesquiterpene synthases in basidiomycota

MB Quin, CM Flynn, GT Wawrzyn, S Choudhary… - …, 2013 - Wiley Online Library
The Basidiomycota fungi represent a diverse source of natural products, particularly the
sesquiterpenoids. Recently, genome sequencing, genome mining, and the subsequent …

A Multiproduct Terpene Synthase from Medicago truncatula Generates Cadalane Sesquiterpenes via Two Different Mechanisms

S Garms, TG Köllner, W Boland - The Journal of organic …, 2010 - ACS Publications
Terpene synthases are responsible for a large diversity of terpene carbon skeletons found in
nature. The multiproduct sesquiterpene synthase MtTPS5 isolated from Medicago truncatula …

Concise total synthesis of agarozizanol B via a strained photocascade intermediate

N Rauscher, L Næsborg, C Jandl… - Angewandte Chemie, 2021 - Wiley Online Library
The prezizane‐type sesquiterpene agarozizanol B was synthesized employing a
photochemical cascade reaction as the key step. Starting from a readily available 1 …

A 1, 6-ring closure mechanism for (+)-δ-cadinene synthase?

JA Faraldos, DJ Miller, V Gonzalez… - Journal of the …, 2012 - ACS Publications
Recombinant (+)-δ-cadinene synthase (DCS) from Gossypium arboreum catalyzes the metal-
dependent cyclization of (E, E)-farnesyl diphosphate (FDP) to the cadinane sesquiterpene δ …

Nerylneryl diphosphate is the precursor of serrulatane, viscidane and cembrane-type diterpenoids in Eremophila species

O Gericke, NL Hansen, GB Pedersen, L Kjaerulff… - BMC plant biology, 2020 - Springer
Abstract Background Eremophila R. Br.(Scrophulariaceae) is a diverse genus of plants with
species distributed across semi-arid and arid Australia. It is an ecologically important genus …

A method for investigating the stereochemical course of terpene cyclisations

P Rabe, J Rinkel, TA Klapschinski, L Barra… - Organic & …, 2016 - pubs.rsc.org
Three sesquiterpene cyclases from Streptomyces scabei 87.22, Streptomyces venezuelae
ATCC 10712 and Streptomyces clavuligerus ATCC 27064 were characterised and their …