Gold derivatives for the treatment of cancer

ERT Tiekink - Critical reviews in oncology/hematology, 2002 - Elsevier
The cytotoxicity and anti-tumour activity screening trials for both gold (I) and gold (III) are
summarised. Gold (I) thiolates employed clinically in the treatment of rheumatoid arthritis …

The anti-cancer properties of gold (III) compounds with dianionic porphyrin and tetradentate ligands

RWY Sun, CM Che - Coordination Chemistry Reviews, 2009 - Elsevier
Gold (III) compounds have long been investigated for anti-cancer treatment. However,
clinical use has often been hampered by their poor stability in solution. A reduction of gold …

Gold (III) complexes as potential antitumor agents: solution chemistry and cytotoxic properties of some selected gold (III) compounds

L Messori, F Abbate, G Marcon, P Orioli… - Journal of medicinal …, 2000 - ACS Publications
Gold (III) complexes generally exhibit interesting cytotoxic and antitumor properties, but until
now, their development has been heavily hampered by their poor stability under …

Medicinal inorganic chemistry

Z Guo, PJ Sadler - Advances in inorganic chemistry, 1999 - Elsevier
Publisher Summary Biomedical inorganic chemistry “Elemental Medicine” is an important
new area of chemistry. Platinum complexes are now among the most widely used drugs for …

Gold (III) complexes with bipyridyl ligands: solution chemistry, cytotoxicity, and DNA binding properties

G Marcon, S Carotti, M Coronnello… - Journal of Medicinal …, 2002 - ACS Publications
Gold (III) compounds generally exhibit significant cytotoxic effects on cancer cell lines and
are of potential interest as antitumor drugs. We report here on the solution chemistry, the …

Gold (III) compounds as anticancer agents: Relevance of gold–protein interactions for their mechanism of action

A Casini, C Hartinger, C Gabbiani, E Mini… - Journal of inorganic …, 2008 - Elsevier
Gold (III) compounds constitute an emerging class of biologically active substances, of
special interest as potential anticancer agents. During the past decade a number of …

Gold coordination complexes as anticancer agents

I Kostova - Anti-Cancer Agents in Medicinal Chemistry-Anti …, 2006 - benthamdirect.com
Metal ions are known to bind with nucleic acids and thereby alter their conformation and
biological function. The metal ion-base interaction depends on the nature of both metal and …

Gold (III) compounds as anticancer drugs

C Gabbiani, A Casini, L Messori - Gold Bulletin, 2007 - Springer
Gold (III) complexes constitute a new class of metallodrugs, of potential interest for cancer
treatment. During the past decade different kinds of gold (III) complexes have been reported …

Original multivalent gold (III) and dual gold (III)–copper (II) conjugated phosphorus dendrimers as potent antitumoral and antimicrobial agents

SM Mignani, N El Brahmi, S El Kazzouli… - molecular …, 2017 - ACS Publications
Original metallophosphorus dendrimers (generation 3, 48 terminal groups) have been
prepared via the complexation of phosphorus dendrimers bearing imino-pyridino end …

New bio-sensitive and biologically active single crystal of pyrimidine scaffold ligand and its gold and platinum complexes: DFT, antimicrobial, antioxidant, DNA …

M Sankarganesh, JD Raja, K Sakthikumar… - Bioorganic …, 2018 - Elsevier
Novel gold and platinum complexes [AuL 2]· Cl, 1 and [PtL 2]· 2Cl, 2 with ligand, 2-methoxy-
6-((2-(4-(trifluoromethyl) pyrimidin-2-yl) hydrazono) methyl) phenol (HL) have been …