Molecular heterogeneity and immunosuppressive microenvironment in glioblastoma

S DeCordova, A Shastri, AG Tsolaki, H Yasmin… - Frontiers in …, 2020 - frontiersin.org
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a poor
prognosis, despite surgical resection combined with radio-and chemotherapy. The major …

[HTML][HTML] Broad targeting of resistance to apoptosis in cancer

RM Mohammad, I Muqbil, L Lowe, C Yedjou… - Seminars in cancer …, 2015 - Elsevier
Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

Glioblastoma multiforme–an overview

K Urbańska, J Sokołowska, M Szmidt… - Contemporary Oncology …, 2014 - termedia.pl
Glioblastoma multiforme is a central nervous system tumor of grade IV histological
malignancy according to the WHO classification. Over 90% of diagnosed glioblastomas …

Stratification of astrocytes in healthy and diseased brain

A Verkhratsky, R Zorec, V Parpura - Brain Pathology, 2017 - Wiley Online Library
Astrocytes, a subtype of glial cells, come in variety of forms and functions. However,
overarching role of these cell is in the homeostasis of the brain, be that regulation of ions …

Emerging treatment strategies for glioblastoma multiforme

SK Carlsson, SP Brothers… - EMBO molecular medicine, 2014 - embopress.org
Glioblastoma multiforme (GBM) is the deadliest form of brain tumor with a more than 90% 5‐
year mortality. GBM has a paltry median survival of 12.6 months attributed to the unique …

Temozolomide nano enabled medicine: promises made by the nanocarriers in glioblastoma therapy

PS Yasaswi, K Shetty, KS Yadav - Journal of Controlled Release, 2021 - Elsevier
Glioblastoma multiforme (GBM) is abnormal cell proliferation of glial cells. GBM is the grade
IV glioma brain cancer which is life-threatening to many individuals affected by this cancer …

Glioblastoma multiforme metastasis outside the CNS: three case reports and possible mechanisms of escape

JD Hamilton, M Rapp, TM Schneiderhan… - Journal of Clinical …, 2014 - ascopubs.org
Primary brain and CNS tumor incidence is approximately 19 per 100,000 individuals per
year in the United States compared with seven per 100,000 individuals worldwide. 1, 2 …

Enhancement of therapies for glioblastoma (GBM) using nanoparticle-based delivery systems

K Wiwatchaitawee, JC Quarterman, SM Geary… - Aaps Pharmscitech, 2021 - Springer
Glioblastoma multiforme (GBM) is the most aggressive type of malignant brain tumor.
Current FDA-approved treatments include surgical resection, radiation, and chemotherapy …

Functional nanoparticles in targeting glioma diagnosis and therapies

M Li, H Deng, H Peng, Q Wang - Journal of nanoscience and …, 2014 - ingentaconnect.com
Successful therapy and diagnosis of glioma is one of the biggest challenges in the
biomedical fields. The incidence is growing gradually around the world. Annually, there are …

Microfluidics-based devices: New tools for studying cancer and cancer stem cell migration

Y Huang, B Agrawal, D Sun, JS Kuo, JC Williams - Biomicrofluidics, 2011 - pubs.aip.org
Cell movement is highly sensitive to stimuli from the extracellular matrix and media.
Receptors on the plasma membrane in cells can activate signal transduction pathways that …