Synthetic alternatives to Matrigel

EA Aisenbrey, WL Murphy - Nature Reviews Materials, 2020 - nature.com
Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

[HTML][HTML] Recent advances in hydrogels for cartilage tissue engineering

SL Vega, MY Kwon, JA Burdick - European cells & materials, 2017 - ncbi.nlm.nih.gov
Articular cartilage is a load-bearing tissue that lines the surface of bones in diarthrodial
joints. Unfortunately, this avascular tissue has a limited capacity for intrinsic repair …

In situ 3D bioprinting with bioconcrete bioink

M Xie, Y Shi, C Zhang, M Ge, J Zhang, Z Chen… - Nature …, 2022 - nature.com
In-situ bioprinting is attractive for directly depositing the therapy bioink at the defective
organs to repair them, especially for occupations such as soldiers, athletes, and drivers who …

Biomaterialomics: Data science-driven pathways to develop fourth-generation biomaterials

B Basu, NH Gowtham, Y Xiao, SR Kalidindi, KW Leong - Acta Biomaterialia, 2022 - Elsevier
Conventional approaches to developing biomaterials and implants require intuitive tailoring
of manufacturing protocols and biocompatibility assessment. This leads to longer …

Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion

EH Nguyen, WT Daly, NNT Le, M Farnoodian… - Nature biomedical …, 2017 - nature.com
The physiological relevance of Matrigel as a cell-culture substrate and in angiogenesis
assays is often called into question. Here, we describe an array-based method for the …

Engineering hydrogel microenvironments to recapitulate the stem cell niche

CM Madl, SC Heilshorn - Annual review of biomedical …, 2018 - annualreviews.org
Stem cells are a powerful resource for many applications including regenerative medicine,
patient-specific disease modeling, and toxicology screening. However, eliciting the desired …

Injectable multifunctional drug delivery system for hard tissue regeneration under inflammatory microenvironments

EAF Bordini, JA Ferreira, N Dubey… - ACS Applied Bio …, 2021 - ACS Publications
Engineering multifunctional hydrogel systems capable of amplifying the regenerative
capacity of endogenous progenitor cells via localized presentation of therapeutics under …

The advancement of biomaterials in regulating stem cell fate

VV Hiew, SFB Simat, PL Teoh - Stem Cell Reviews and Reports, 2018 - Springer
Stem cells are well-known to have prominent roles in tissue engineering applications.
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can differentiate …

Substrate mechanics dictate cell-cell communication by gap junctions in stem cells from human apical papilla

C Zhou, D Zhang, W Du, J Zou, X Li, J Xie - Acta biomaterialia, 2020 - Elsevier
It is recognized that the interaction between cells and their physical microenvironment plays
a fundamental role in controlling cell behaviors and even in determining cell fate. Any …

Thiol-Mediated Chemoselective Strategies for In Situ Formation of Hydrogels

J Su - Gels, 2018 - mdpi.com
Hydrogels are three-dimensional networks composed of hydrated polymer chains and have
been a material of choice for many biomedical applications such as drug delivery …