[HTML][HTML] Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectives

X Niu, N Li, Z Du, X Li - Bioactive Materials, 2023 - Elsevier
The osteochondral defect repair has been most extensively studied due to the rising
demand for new therapies to diseases such as osteoarthritis. Tissue engineering has been …

Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions

Z Wang, H Le, Y Wang, H Liu, Z Li, X Yang, C Wang… - Bioactive Materials, 2022 - Elsevier
The development of interdisciplinary biomedical engineering brings significant
breakthroughs to the field of cartilage regeneration. However, cartilage defects are …

[HTML][HTML] Recent development in multizonal scaffolds for osteochondral regeneration

L Yu, S Cavelier, B Hannon, M Wei - Bioactive Materials, 2023 - Elsevier
Osteochondral (OC) repair is an extremely challenging topic due to the complex biphasic
structure and poor intrinsic regenerative capability of natural osteochondral tissue. In …

Hydrogel drug delivery systems for bone regeneration

L Bai, G Tao, M Feng, Y Xie, S Cai, S Peng, J Xiao - Pharmaceutics, 2023 - mdpi.com
With the in-depth understanding of bone regeneration mechanisms and the development of
bone tissue engineering, a variety of scaffold carrier materials with desirable …

[HTML][HTML] Chondroinductive/chondroconductive peptides and their-functionalized biomaterials for cartilage tissue engineering

M Zhu, W Zhong, W Cao, Q Zhang, G Wu - Bioactive materials, 2022 - Elsevier
The repair of articular cartilage defects is still challenging in the fields of orthopedics and
maxillofacial surgery due to the avascular structure of articular cartilage and the limited …

[HTML][HTML] Bioactive peptides for boosting stem cell culture platform: Methods and applications

AA Dayem, SB Lee, KM Lim, A Kim, HJ Shin… - Biomedicine & …, 2023 - Elsevier
Peptides, short protein fragments, can emulate the functions of their full-length native
counterparts. Peptides are considered potent recombinant protein alternatives due to their …

Integrated polycaprolactone microsphere-based scaffolds with biomimetic hierarchy and tunable vascularization for osteochondral repair

X Gu, Y Zha, Y Li, J Chen, S Liu, Y Du, S Zhang… - Acta Biomaterialia, 2022 - Elsevier
Osteochondral lesion potentially causes a variety of joint degenerative diseases if it cannot
be treated effectively and timely. Microfracture as the conservative surgical choice achieves …

[HTML][HTML] Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair

L Zhou, J Xu, A Schwab, W Tong, J Xu, L Zheng, Y Li… - Bioactive Materials, 2023 - Elsevier
As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very
limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden …

Progress on biomimetic mineralization and materials for hard tissue regeneration

J Wang, Q Liu, Z Guo, H Pan, Z Liu… - … Biomaterials Science & …, 2021 - ACS Publications
Biomineralization is a process in which natural organisms regulate the crystal growth of
inorganic minerals, resulting in hierarchical structured biominerals with excellent properties …

The effect of multi-material architecture on the ex vivo osteochondral integration of bioprinted constructs

ML Bedell, Z Wang, KJ Hogan, AL Torres, HA Pearce… - Acta biomaterialia, 2023 - Elsevier
Extrusion bioprinted constructs for osteochondral tissue engineering were fabricated to
study the effect of multi-material architecture on encapsulated human mesenchymal stem …