Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …

The term “zoonosis” denotes diseases transmissible among vertebrate animals and
humans. These diseases constitute a significant public health challenge, comprising 61% of …

Abstract Cyclin-dependent kinase 2 (CDK2) is a vital protein for controlling cell cycle
progression that is critically associated with various malignancies and its inhibition could …

Introduction: Leishmaniasis is a disease with high mortality rates and approximately 1.5
million new cases each year. Despite the new approaches and advances to fight the …

Caffeic acid and related natural compounds were previously described as Leishmania
amazonensis arginase (L-ARG) inhibitors, and against the whole parasite in vitro. In this …

Leishmaniasis is a disease caused by a protozoan of the genus Leishmania, affecting
millions of people, mainly in tropical countries, due to poor social conditions and low …

Among the menacing diseases, cancer needs the most attention as millions of people are
affected by it worldwide. Genetic and environmental factors play a pivotal role in causing …

Cutaneous leishmaniasis (CL) is a spectrum of clinical manifestations characterized by
severe skin ulcerations that leads to social stigma. There are limited treatment options for …

Over the years, the development of bioactive heterocycles has aroused the interest of the
scientific community, because in general, these heterocycles are strategic in maintaining life …

Leishmaniasis are neglected infectious diseases caused by kinetoplastid protozoan
parasites from the genus Leishmania. These sicknesses are present mainly in tropical …