Network analysis for a network disorder: the emerging role of graph theory in the study of epilepsy

BC Bernhardt, L Bonilha, DW Gross - Epilepsy & Behavior, 2015 - Elsevier
Recent years have witnessed a paradigm shift in the study and conceptualization of
epilepsy, which is increasingly understood as a network-level disorder. An emblematic case …

Imaging structural and functional brain networks in temporal lobe epilepsy

BC Bernhardt, SJ Hong, A Bernasconi… - Frontiers in human …, 2013 - frontiersin.org
Early imaging studies in temporal lobe epilepsy (TLE) focused on the search for mesial
temporal sclerosis, as its surgical removal results in clinically meaningful improvement in …

Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression

S Larivière, J Royer, R Rodríguez-Cruces… - Nature …, 2022 - nature.com
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations,
but associations between neurobiological mechanisms and macroscale connectomics …

Deep learning applied to whole‐brain connectome to determine seizure control after epilepsy surgery

E Gleichgerrcht, B Munsell, S Bhatia… - …, 2018 - Wiley Online Library
Objective We evaluated whether deep learning applied to whole‐brain presurgical structural
connectomes could be used to predict postoperative seizure outcome more accurately than …

Connectomics and graph theory analyses: novel insights into network abnormalities in epilepsy

E Gleichgerrcht, M Kocher, L Bonilha - Epilepsia, 2015 - Wiley Online Library
The assessment of neural networks in epilepsy has become increasingly relevant in the
context of translational research, given that localized forms of epilepsy are more likely to be …

Structural substrates for resting network disruption in temporal lobe epilepsy

NL Voets, CF Beckmann, DM Cole, SJ Hong… - Brain, 2012 - academic.oup.com
Magnetic resonance imaging methods that measure interregional brain signalling at rest
have been advanced as powerful tools to probe organizational properties of functional …

Age, plasticity, and homeostasis in childhood brain disorders

M Dennis, BJ Spiegler, JJ Juranek, ED Bigler… - Neuroscience & …, 2013 - Elsevier
It has been widely accepted that the younger the age and/or immaturity of the organism, the
greater the brain plasticity, the young age plasticity privilege. This paper examines the …

Automated detection of hippocampal sclerosis using clinically empirical and radiomics features

J Mo, Z Liu, K Sun, Y Ma, W Hu, C Zhang, Y Wang… - …, 2019 - Wiley Online Library
Objective Temporal lobe epilepsy is a common form of epilepsy that might be amenable to
surgery. However, magnetic resonance imaging (MRI)‐negative hippocampal sclerosis (HS) …

Whole-brain MRI phenotyping in dysplasia-related frontal lobe epilepsy

SJ Hong, BC Bernhardt, DS Schrader, N Bernasconi… - Neurology, 2016 - AAN Enterprises
Objective: To perform whole-brain morphometry in patients with frontal lobe epilepsy and
evaluate the utility of group-level patterns for individualized diagnosis and prognosis …

Preferential susceptibility of limbic cortices to microstructural damage in temporal lobe epilepsy: A quantitative T1 mapping study

BC Bernhardt, F Fadaie, RV de Wael, SJ Hong, M Liu… - Neuroimage, 2018 - Elsevier
The majority of MRI studies in temporal lobe epilepsy (TLE) have utilized morphometry to
map widespread cortical alterations. Morphological markers, such as cortical thickness or …