Childhood maltreatment is the most important preventable risk factor for psychiatric
disorders. Maltreated individuals typically develop psychiatric disorders at an earlier age …

An extensive literature on childhood adversity and neurodevelopment has emerged over the
past decade. We evaluate two conceptual models of adversity and neurodevelopment—the …

Background Transdiagnostic processes confer risk for multiple types of psychopathology
and explain the co-occurrence of different disorders. For this reason, transdiagnostic …

We review the three prevailing approaches—specificity, cumulative risk, and dimensional
models—to conceptualizing the developmental consequences of early-life adversity and …

Life history theory argues that exposure to early life adversity (ELA) accelerates
development, although existing evidence for this varies. We present a meta-analysis and …

Childhood maltreatment is associated with increased risk for most forms of psychopathology.
We examine emotion dysregulation as a transdiagnostic mechanism linking maltreatment …

Despite long-standing interest in the influence of adverse early experiences on mental
health, systematic scientific inquiry into childhood adversity and developmental outcomes …

Highlights•Enhanced threat processing is a mechanism linking child trauma to
psychopathology.•Information processing biases and altered emotional learning are key …

Investigating the developmental sequelae of early life stress has provided researchers the
opportunity to examine adaptive responses to extreme environments. A large body of work …

Although rates of child maltreatment are declining, more than 600,000 children in the United
States are substantiated victims of abuse or neglect. The focus of this review is on the …