Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Carbon monoxide and its controlled release: therapeutic application, detection, and development of carbon monoxide releasing molecules (CORMs) miniperspective

K Ling, F Men, WC Wang, YQ Zhou… - Journal of Medicinal …, 2017 - ACS Publications
Carbon monoxide (CO) is attracting increasing attention because of its role as a
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …

Redox regulation of mitochondrial function

DE Handy, J Loscalzo - Antioxidants & redox signaling, 2012 - liebertpub.com
Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …

Biological signaling by carbon monoxide and carbon monoxide-releasing molecules

R Motterlini, R Foresti - American Journal of Physiology …, 2017 - journals.physiology.org
Carbon monoxide (CO) is continuously produced in mammalian cells during the
degradation of heme. It is a stable gaseous molecule that reacts selectively with transition …

[图书][B] Handbook Of Porphyrin Science: With Applications To Chemistry, Physics, Materials Science, Engineering, Biology And Medicine (Volumes 6-10)

KM Kadish, R Guilard, KM Smith - 2010 - books.google.com
This is the second set of Handbook of Porphyrin Science. Porphyrins, phthalocyanines and
their numerous analogues and derivatives are materials of tremendous importance in …

Heme oxygenase-1 and carbon monoxide in the heart: the balancing act between danger signaling and pro-survival

LE Otterbein, R Foresti, R Motterlini - Circulation research, 2016 - Am Heart Assoc
Understanding the processes governing the ability of the heart to repair and regenerate after
injury is crucial for developing translational medical solutions. New avenues of exploration …

Harnessing carbon monoxide-releasing platforms for cancer therapy

Y Zhou, W Yu, J Cao, H Gao - Biomaterials, 2020 - Elsevier
Carbon monoxide (CO) is a gaseous molecule that has drawn growing concerns for cancer
treatment, due to its multifaceted regulation of cellular function and the tumor …

The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote …

I Andreadou, EK Iliodromitis, T Rassaf… - British journal of …, 2015 - Wiley Online Library
Ischaemic heart disease is one of the leading causes of morbidity and mortality worldwide.
The development of cardioprotective therapeutic agents remains a partly unmet need and a …

A modern literature review of carbon monoxide poisoning theories, therapies, and potential targets for therapy advancement.

JD Roderique, CS Josef, MJ Feldman, BD Spiess - Toxicology, 2015 - Elsevier
The first descriptions of carbon monoxide (CO) and its toxic nature appeared in the literature
over 100 years ago in separate publications by Drs. Douglas and Haldane. Both men …

Carbon monoxide signaling: examining its engagement with various molecular targets in the context of binding affinity, concentration, and biologic response

Z Yuan, LK De La Cruz, X Yang, B Wang, Q Ma - Pharmacological Reviews, 2022 - Elsevier
Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …