Translational medicine in the field of ablative fractional laser (AFXL)-assisted drug delivery: a critical review from basics to current clinical status

M Haedersdal, AM Erlendsson, U Paasch… - Journal of the American …, 2016 - Elsevier
Background Ablative fractional lasers enhance uptake of topical therapeutics and the
concept of fractional laser-assisted drug delivery has now been taken into clinical practice …

Laser assisted drug delivery: a review of an evolving technology

LR Sklar, CT Burnett, JS Waibel… - Lasers in surgery and …, 2014 - Wiley Online Library
Background Topically applied drugs have a relatively low cutaneous bioavailability.
Objective This article reviews the existing applications of laser assisted drug delivery, a …

Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin

J Bolsoni, D Liu, F Mohabatpour, R Ebner… - ACS …, 2023 - ACS Publications
Despite exciting advances in gene editing, the efficient delivery of genetic tools to
extrahepatic tissues remains challenging. This holds particularly true for the skin, which …

Transdermal delivery of molecules is limited by full epidermis, not just stratum corneum

SN Andrews, E Jeong, MR Prausnitz - Pharmaceutical research, 2013 - Springer
Purpose Most methods to increase transdermal drug delivery focus on increasing stratum
corneum permeability, without addressing the need to increase permeability of viable …

Enhancement of skin permeability with thermal ablation techniques: concept to commercial products

R Parhi, A Mandru - Drug delivery and translational research, 2021 - Springer
Traditionally, the skin is considered as a protective barrier which acts as a highly
impermeable region of the human body. But in recent times, it is recognized as a specialized …

Heat: a highly efficient skin enhancer for transdermal drug delivery

S Szunerits, R Boukherroub - Frontiers in bioengineering and …, 2018 - frontiersin.org
Advances in materials science and bionanotechnology have allowed the refinements of
current drug delivery systems, expected to facilitate the development of personalized …

Fundamentals of fractional laser-assisted drug delivery: an in-depth guide to experimental methodology and data interpretation

E Wenande, RR Anderson, M Haedersdal - Advanced drug delivery …, 2020 - Elsevier
In the decade since their advent, ablative fractional lasers have emerged as powerful tools
to enhance drug delivery to and through the skin. Effective and highly customizable, laser …

Hollow copper sulfide nanoparticle‐mediated transdermal drug delivery

S Ramadan, L Guo, Y Li, B Yan, W Lu - Small, 2012 - Wiley Online Library
A photothermal ablation‐enhanced transdermal drug delivery methodology is developed
based on hollow copper sulfide nanoparticles (HCuSNPs) with intense photothermal …

Transdermal and intravenous nano drug delivery systems: present and future

M Sharma - Applications of targeted nano drugs and delivery …, 2019 - Elsevier
Nanotechnology has opened new vistas in nano drug formulation and fabrication. In the
market many different types of nano drugs are now available, which are not only much safer …

Lasers as an approach for promoting drug delivery via skin

CH Lin, IA Aljuffali, JY Fang - Expert opinion on drug delivery, 2014 - Taylor & Francis
Introduction: Using lasers can be an effective drug permeation-enhancement approach for
facilitating drug delivery into or across the skin. The controlled disruption and ablation of the …