There is a long-standing assumption that naive CD4+ and CD8+ T cells are largely
homogeneous populations despite the extraordinary diversity of their T cell receptors (TCR) …

The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for
antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we …

Regulatory T cells (Tregs) are present in lymphoid and nonlymphoid tissues where they
restrict immune activation, prevent autoimmunity, and regulate inflammation. Tregs in …

Highlights•Surrogate markers of tonic TCR signaling include CD5, Ly6C, and Nur77-
GFP.•Tonic (or basal) TCR signaling in response to self-antigens can vary in intensity.•Naive …

Studying the spatial distribution of proteins provides the basis for understanding the biology,
molecular repertoire, and architecture of every human cell. The Human Protein Atlas (HPA) …

CD4+ T cells have a remarkable potential to differentiate into diverse effector lineages
following activation. Here, we probe the heterogeneity present among naive CD4+ T cells …

Cells rely on activity-dependent protein-protein interactions to convey biological signals. For
chimeric antigen receptor (CAR) T cells containing a 4-1BB costimulatory domain, receptor …

Inhibiting the functional role of negative regulators in immune cells is an effective approach
for developing immunotherapies. The serine/threonine kinase hematopoietic progenitor …

The T cell receptor (TCR) determines specificity and affinity for both foreign and self-
peptides presented by the major histocompatibility complex (MHC). Although the strength of …

Chimeric antigen receptor engineered T cells (CAR-T) have demonstrated promising clinical
efficacy in B-cell malignancies, and the approach has been extended to T-cell malignancies …