Nitrous oxide exerts rewarding effect via regulating D1 receptor and BDNF pathway in ventral tegmental area-nucleus accumbens dopamine circuit

WQ Li, SN Liu, SC Yang, X Lin, ZJ Zhang - Translational Psychiatry, 2025 - nature.com
Recreational use of nitrous oxide (N2O) has risen dramatically over the past decades. This
study aimed to examine its rewarding effect and the underlying mechanisms. The exposure …

Paternal cocaine-seeking motivation defines offspring's vulnerability to addiction by down-regulating GABAergic GABRG3 in the ventral tegmental area

J Cui, N Huang, G Fan, T Pan, K Han, C Jiang… - Translational …, 2024 - nature.com
Epidemiological investigations indicate that parental drug abuse experiences significantly
influenced the addiction vulnerability of offspring. Studies using animal models have shown …

Acute and chronic effects by nicotine on striatal neurotransmission and synaptic plasticity in the female rat brain

E Lucente, B Söderpalm, M Ericson… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction Tobacco use is in part a gendered activity, yet neurobiological studies outlining
the effect by nicotine on the female brain are scarce. The aim of this study was to outline …

Biomimetic optogenetic stimulation of ventral tegmental area GABAergic projections to the tegmental pedunculopontine nucleus is sufficient to elicit artificial naïve …

SR Lovejoy - 2023 - search.proquest.com
Morphine injections into the Ventral Tegmental Area (VTA) produce reward behaviour.
Lesions of the Tegmental Pedunculopontine Nucleus (TPP) block these rewarding effects in …

Brain Resting-State Salience and Executive Network Connectivity Predictors of Smoking Progression, Nicotine-Enhanced Reward Sensitivity, and Depression

MP Gunn - 2024 - search.proquest.com
The study's objective was to assess whether resting-state regional functional connectivity
and current source density (CSD) measured during smoking abstinence predict smoking …