Type 2 diabetes mellitus and heart failure: a scientific statement from the American Heart Association and the Heart Failure Society of America: this statement does not …

SM Dunlay, MM Givertz, D Aguilar, LA Allen, M Chan… - Circulation, 2019 - Am Heart Assoc
Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of
morbidity and mortality in patients with established disease. Secular trends in the …

Clinical update: cardiovascular disease in diabetes mellitus: atherosclerotic cardiovascular disease and heart failure in type 2 diabetes mellitus–mechanisms …

CC Low Wang, CN Hess, WR Hiatt, AB Goldfine - Circulation, 2016 - Am Heart Assoc
Cardiovascular disease remains the principal cause of death and disability among patients
with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying …

Contributory risk and management of comorbidities of hypertension, obesity, diabetes mellitus, hyperlipidemia, and metabolic syndrome in chronic heart failure: a …

B Bozkurt, D Aguilar, A Deswal, SB Dunbar… - Circulation, 2016 - Am Heart Assoc
Elevated levels of diastolic BP and especially systolic BP (SBP) are major risk factors for the
development of HF. 18, 19 One of the most impactful observations from the Framingham …

Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes

PM Seferović, WJ Paulus - European heart journal, 2015 - academic.oup.com
Diabetes mellitus-related cardiomyopathy (DMCMP) was originally described as a dilated
phenotype with eccentric left ventricular (LV) remodelling and systolic LV dysfunction …

Heart failure in diabetes: effects of anti-hyperglycaemic drug therapy

RE Gilbert, H Krum - The Lancet, 2015 - thelancet.com
Individuals with diabetes are not only at high risk of developing heart failure but are also at
increased risk of dying from it. Fortunately, antiheart failure therapies such as angiotensin …

Heart failure: a cardiovascular outcome in diabetes that can no longer be ignored

JJV McMurray, HC Gerstein, RR Holman… - The lancet Diabetes & …, 2014 - thelancet.com
In patients with type 1 or type 2 diabetes, glycaemic exposure assessed as HbA 1c
correlates strongly with risk of future microvascular and macrovascular complications …

Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension

L Van Heerebeek, N Hamdani, ML Handoko… - Circulation, 2008 - Am Heart Assoc
Background—Excessive diastolic left ventricular stiffness is an important contributor to heart
failure in patients with diabetes mellitus. Diabetes is presumed to increase stiffness through …

Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus

A Lejay, F Fang, R John, JAD Van, M Barr… - Journal of Molecular and …, 2016 - Elsevier
Ischemia/reperfusion, which is characterized by deficient oxygen supply and subsequent
restoration of blood flow, can cause irreversible damages to tissue. Mechanisms contributing …

Diabetes mellitus worsens diastolic left ventricular dysfunction in aortic stenosis through altered myocardial structure and cardiomyocyte stiffness

I Falcao-Pires, N Hamdani, A Borbély, C Gavina… - Circulation, 2011 - Am Heart Assoc
Background—Aortic stenosis (AS) and diabetes mellitus (DM) are frequent comorbidities in
aging populations. In heart failure, DM worsens diastolic left ventricular (LV) dysfunction …

Association between diabetes mellitus and post‐discharge outcomes in patients hospitalized with heart failure: findings from the EVEREST trial

S Sarma, RJ Mentz, MJ Kwasny… - European journal of …, 2013 - Wiley Online Library
Aims We evaluated the impact of diabetes mellitus (DM) and diabetic therapy on outcomes
in patients with reduced ejection fraction (EF) after hospitalization for heart failure (HF). DM …