Sleep-induced apnea and disordered breathing refers to intermittent, cyclical cessations or
reductions of airflow, with or without obstructions of the upper airway (OSA). In the presence …

The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …

Key points A strong correlation between disordered breathing patterns, elevated
sympathetic nerve activity and enhanced chemoreflex sensitivity exists in patients with heart …

Chronic exposure to intermittent hypoxia (CIH) increases carotid sinus nerve activity in
normoxia and in response to acute hypoxia. We hypothesized that CIH augments basal and …

Heart failure (HF) is a complex clinical syndrome affecting roughly 26 million people
worldwide. Increased sympathetic drive is a hallmark of HF and is associated with disease …

In sepsis, systemic inflammatory response syndrome (SIRS), and multiorgan dysfunction
syndrome (MODS), a severe prognostically relevant cardiac autonomic dysfunction exists …

hypoxemia, and as hypoxia ensues, the magnitudes of SNA and PNA increase
asymptotically and are maintained, whereas the ventilatory rate increases transiently and …

Non‐technical summary Activation of the sympathetic nervous system hastens the rate of
progression and severity of chronic heart failure (CHF). Chemically sensitive nerves in the …

Neurohumoral activation has been recognized as one of the hallmarks in the compensatory
response during the development of chronic heart failure (CHF), whatever its origin. 1–4 A …

Rationale: Increased sympathetic nerve activity has been linked to the pathogenesis of
hypertension in humans and animal models. Enhanced peripheral chemoreceptor sensitivity …