Abstract Hydrogen peroxide (H 2 O 2) is involved in various signal transduction pathways
and cell fate decisions. The mechanism of the so called “redox signaling” includes the H 2 O …

Nitric oxide (NO) is a short-lived, pleiotropic molecule that affects numerous critical functions
in the body. Presently, there are markedly conflicting findings in the literature regarding NO …

Lactobacillus paracasei is a major probiotic and is well known for its anti-inflammatory
properties. Thus, we investigated the effects of L. paracasei-derived extracellular vesicles …

Introduction Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer
with no effective targeted therapy. Inducible nitric oxide synthase (iNOS) is associated with …

Gas therapy, an emerging cancer treatment method of inflammation‐related diseases, has
recently received substantial attention. The rapid advances in nanomedicine and …

One of the hallmarks of malignancy is the polarization of tumor-associated macrophages
(TAMs) from a pro-immune (M1-like) phenotype to an immune-suppressive (M2-like) …

Casticin, a polymethoxyflavone derived from natural plants, has biological activities
including induction of cell apoptosis. In this study, we showed the beneficial effects of …

Nitric oxide (NO), a free radical, plays a critical role in a wide range of physiological and
pathological processes. Due to its pleiotropic function, it has been widely investigated in …

Pharmacological profile of phytochemicals has attracted much attention to their use in
disease therapy. Since cancer is a major problem for public health with high mortality and …

Colorectal cancer (CRC) is one of the most lethal malignancies worldwide and CRC therapy
remains unsatisfactory. In recent decades, nitric oxide (NO)—a free-radical gas—plus its …