Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain
K Obernier, A Alvarez-Buylla - Development, 2019 - journals.biologists.com
In the adult rodent brain, neural stem cells (NSCs) persist in the ventricular-subventricular
zone (V-SVZ) and the subgranular zone (SGZ), which are specialized niches in which young …
zone (V-SVZ) and the subgranular zone (SGZ), which are specialized niches in which young …
Recent insights on astrocyte mechanisms in CNS homeostasis, pathology, and repair
CG Hart, S Karimi‐Abdolrezaee - Journal of neuroscience …, 2021 - Wiley Online Library
Astrocytes play essential roles in development, homeostasis, injury, and repair of the central
nervous system (CNS). Their development is tightly regulated by distinct spatial and …
nervous system (CNS). Their development is tightly regulated by distinct spatial and …
Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1
An aged circulatory environment can activate microglia, reduce neural precursor cell activity
and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate …
and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate …
[HTML][HTML] A common embryonic origin of stem cells drives developmental and adult neurogenesis
New neurons arise from quiescent adult neural progenitors throughout life in specific
regions of the mammalian brain. Little is known about the embryonic origin and …
regions of the mammalian brain. Little is known about the embryonic origin and …
Developmental emergence of adult neural stem cells as revealed by single-cell transcriptional profiling
Adult neural stem cells (NSCs) derive from embryonic precursors, but little is known about
how or when this occurs. We have addressed this issue using single-cell RNA sequencing …
how or when this occurs. We have addressed this issue using single-cell RNA sequencing …
Development of ependymal and postnatal neural stem cells and their origin from a common embryonic progenitor
SA Redmond, M Figueres-Oñate, K Obernier… - Cell reports, 2019 - cell.com
The adult mouse brain contains an extensive neurogenic niche in the lateral walls of the
lateral ventricles. This epithelium, which has a unique pinwheel organization, contains …
lateral ventricles. This epithelium, which has a unique pinwheel organization, contains …
[HTML][HTML] Regulation of neurogenesis in the adult and aging brain
L Katsimpardi, PM Lledo - Current opinion in neurobiology, 2018 - Elsevier
Neural stem cells (NSCs) represent a remarkable developmental unit, necessary for the
proper functioning of neurogenesis, by retaining their plasticity to self-renew and give rise to …
proper functioning of neurogenesis, by retaining their plasticity to self-renew and give rise to …
Autocrine Mfge8 signaling prevents developmental exhaustion of the adult neural stem cell pool
Adult neurogenesis, arising from quiescent radial-glia-like neural stem cells (RGLs), occurs
throughout life in the dentate gyrus. How neural stem cells are maintained throughout …
throughout life in the dentate gyrus. How neural stem cells are maintained throughout …
Quiescent neural stem cells for brain repair and regeneration: lessons from model systems
Neural stem cells (NSCs) are multipotent progenitors that are responsible for producing all
of the neurons and macroglia in the nervous system. In adult mammals, NSCs reside …
of the neurons and macroglia in the nervous system. In adult mammals, NSCs reside …
ZEB1 represses neural differentiation and cooperates with CTBP2 to dynamically regulate cell migration during neocortex development
Zinc-finger E-box binding homeobox 1 (Zeb1) is a key regulator of epithelial-mesenchymal
transition and cancer metastasis. Mutation of ZEB1 is associated with human diseases and …
transition and cancer metastasis. Mutation of ZEB1 is associated with human diseases and …