Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Herpes simplex virus type 1 (HSV-1) is highly prevalent in humans and can reach the brain
without evident clinical symptoms. Once in the central nervous system (CNS), the virus can …

Herpes simplex encephalitis (HSE) is the most common form of acute viral encephalitis in
industrialized countries. Type I interferon (IFN) is important for control of herpes simplex …

Neurotropic herpesviruses can establish lifelong infection in humans and contribute to
severe diseases including encephalitis and neurodegeneration. However, the mechanisms …

Herpes simplex virus (HSV) is the main cause of viral encephalitis in the Western world, and
the type I interferon (IFN) system is important for antiviral control in the brain. Here, we have …

Among all major organs, the brain is one of the most susceptible to the inexorable effects of
aging. Throughout the last decades, several studies in human cohorts and animal models …

Herpes simplex viruses are ubiquitous human pathogens represented by two distinct
serotypes: herpes simplex virus (HSV) type 1 (HSV-1); and HSV type 2 (HSV-2). In the …

Herpes virus type 1 (HSV‐1) is one of the most widespread human pathogens and accounts
for more than 90% of cases of herpes simplex encephalitis (HSE) causing severe and …

Specialized, differentiated cells often perform unique tasks that require them to maintain a
stable phenotype. Multiciliated ependymal cells (ECs) are unique glial cells lining the brain …

The detection of nucleic acids by the innate immune system is an essential host response
during viral infection. In recent years, a number of immune sensors capable of recognizing …