In the 15 years since the discovery of hepatitis C virus (HCV), much has been learned about
its role as a major causative agent of human liver disease and its ability to persist in the face …

Viral infection of mammalian cells rapidly triggers intracellular signalling events leading to
interferon α/β production and a cellular antiviral state. This 'host response'is our first line of …

Summary Severe-acute-respiratory-syndrome-related coronavirus 2 (SARS-CoV-2) is the
positive-sense RNA virus that causes coronavirus disease 2019 (COVID-19). The genome …

Over the past two decades, comparative sequence analysis using codon-substitution
models has been honed into a powerful and popular approach for detecting signatures of …

Virus-responsive signaling pathways that induce alpha/beta interferon production and
engage intracellular immune defenses influence the outcome of many viral infections. The …

West Nile virus (WNV) is an arthropod-borne, positive-sense RNA virus that poses an
increasing global threat due to warming climates and lack of effective therapeutics. Like …

The hepatitis C virus (HCV) is a positive-strand RNA virus belonging to the Flaviviridae. Its
genome carries at either end highly conserved nontranslated regions (NTRs) containing cis …

C. Proteolytic Processing of Structural Proteins D. Proteolytic Processing of Nonstructural
Proteins E. Cis-Acting RNA Sequences Required for Replication F. Mechanism of RNA …

The role of the hepatitis C virus (HCV) p7 protein in the virus life cycle is not known. Previous
in vitro data indicated that this 63-aa polypeptide is located in the endoplasmic reticulum …

Most RNA viruses infecting mammals and other vertebrates show profound suppression of
CpG and UpA dinucleotide frequencies. To investigate this functionally, mutants of the …