Mammalian promoters belong to two different categories in terms of base composition and
DNA methylation. In humans and mice, approximately 60% of all promoters colocalize with …

The nuclear genomes of vertebrates are mosaics of isochores, very long stretches (≫
300kb) of DNA that are homogeneous in base composition and are compositionally …

Aberrant methylation of promoter CpG islands in cancer is associated with silencing of tumor-
suppressor genes, and age-dependent hypermethylation in normal appearing mucosa may …

Of the estimated 45 000 CpG islands in the human genome, the overwhelming majority are
found at the 5′ ends of genes and their identification and cloning are proving very useful for …

Preliminary estimates suggest that gene number, and hence biological complexity,
increased suddenly at two periods of macroevolutionary change (the origin of eukaryotes …

The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …

The term genome was first introduced by German botanist Hans Winkler in the early 19th
century to describe the eukaryotic chromosome. It gained considerable attention through the …

▪ Abstract The genomes from three mammals (human, mouse, and rat), two worms, and
several yeasts have been sequenced, and more genomes will be completed in the near …

Results: CpGProD is an application for identifying mammalian promoter regions associated
with CpG islands in large genomic sequences. Although it is strictly dedicated to this …

Purpose: The major aim of this study was to investigate the role of DNA methylation (referred
to as methylation) on miRNA silencing in non–small cell lung cancers (NSCLC) …