An evidence‐based clinical guideline for the diagnosis and management of Paget's disease
of bone (PDB) was developed using GRADE methodology, by a Guideline Development …

Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous
advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to …

Bisphosphonates inhibit bone resorption and are therapeutically effective in diseases of
increased bone turnover, such as Paget's disease and hypercalcemia of malignancy. The …

Breast cancer has a prodigious capacity to metastasize to bone. In women with advanced
breast cancer and bone metastases, bisphosphonates reduce the incidence of …

PURPOSE Osteolytic metastases often give rise to hypercalcemia, fracture, and bone pain,
and occur commonly in patients with recurrent breast cancer. We assessed the …

Only a few textbooks dealing specifically with pediatric X-ray diagnosis have been published
in 50 years of diagnostic roentgenology. There was, until now, only one such book in the …

Bisphosphonates inhibit bone resorption in vivo and in vitro by unknown mechanisms. The
effect of bisphosphonates on the formation of osteoclasts from their mononuclear …

Paget's disease of bone is a common disease characterised by focal areas of increased
bone turnover, affecting one or several bones throughout the skeleton. Paget's disease is …

Paget's disease of bone is a localized, monostotic or polyostotic disease characterized by
increased bone remodeling, bone hypertrophy, and abnormal bone structure that leads in …

Three new bisphosphonates of various chain length, namely, 4-amino-1-hydroxybutylidene-
1, 1-bisphosphonate (AHBuBP), 5-amino-1-hydroxypentylidene-1, 1-bisphosphonate …