The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Mitochondrial stress releases mitochondrial DNA (mtDNA) into the cytosol, thereby
triggering the type Ι interferon (IFN) response. Mitochondrial outer membrane …

Adult cardiomyocytes are postmitotic cells that undergo very limited cell division. Thus,
cardiomyocyte death as occurs during myocardial infarction has very detrimental …

Ca 2+ is a ubiquitous intracellular messenger that controls diverse cellular functions but can
become toxic and cause cell death. Selective control of specific targets depends on …

Calcium is used in many cellular processes and is maintained within the cell as free calcium
at low concentrations (approximately 100 nM), compared with extracellular (millimolar) …

Impairments in neuronal intracellular calcium (iCa2+) handling may contribute to
Alzheimer's disease (AD) development. Metabolic dysfunction and progressive neuronal …

Septic cardiomyopathy is characterized by impaired contractive function with mitochondrial
dysregulation. Songorine is a typical active C 20-diterpene alkaloid from the lateral root of …

In recent years, rapid discoveries have been made relating to Ca 2+ handling at specific
organelles that have important implications for whole-cell Ca 2+ homeostasis. In particular …

Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …