Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …

The study of homologous recombination has its historical roots in meiosis. In this context,
recombination occurs as a programmed event that culminates in the formation of crossovers …

Meiosis is the cell division that reshuffles genetic information between generations.
Recently, much progress has been made in understanding this process; in particular, the …

Holliday junctions (HJs) are four-way DNA intermediates that form during homologous
recombination, and their efficient resolution is essential for chromosome segregation. Here …

Four-way DNA intermediates, called Holliday junctions (HJs), can form during meiotic and
mitotic recombination, and their removal is crucial for chromosome segregation. A group of …

Sexually reproducing eukaryotes use recombination between homologous chromosomes to
promote chromosome segregation during meiosis. Meiotic recombination is almost …

Proper number and placement of meiotic crossovers is vital to chromosome segregation,
with failures in normal crossover distribution often resulting in aneuploidy and infertility …

Holliday junctions (HJs) are X-shaped DNA structures that arise during homologous
recombination, which must be removed to enable chromosome segregation. The SLX1 and …

Sexual reproduction requires the production of haploid gametes (sperm and egg) with only
one copy of each chromosome; fertilization then restores the diploid chromosome content in …

The mismatch repair (MMR) family complexes Msh4-Msh5 and Mlh1-Mlh3 act with Exo1 and
Sgs1-Top3-Rmi1 in a meiotic double strand break repair pathway that results in the …