A remaining challenge in the synthetic chemistry field is formation of all-carbon quaternary
centers, a feature found in many natural products, particularly in spirocycle systems. 1 …

The chemistry of organoelement compounds is now one of the most rapidly developing
fields of research, regarding both fundamental science and solution of applied problems …

The catalytic enantioselective assembly of spirocyclic molecules featuring a spiro quaternary
carbon stereocenter is currently of great interest because such privileged 3D structures are …

Functionalized chiral indole derivatives are privileged and versatile organic frameworks
encountered in numerous pharmaceutically active agents and biologically active natural …

The structures of natural products from a variety of sources contain spirocycles, two rings
that share a common atom. The spiro motif is finding increasing inclusion in drug …

Spirocyclic frameworks have attracted synthetic practitioners due to their unique three-
dimensional assembly, improved metabolic stability, solubility, and increased molecular …

A mild and convenient visible-light-induced method has been developed for the construction
of 3-sulfonyl and 3-sulfenyl azaspiro [4, 5] trienones through metal-free difunctionalization of …

Prompted by the increasing interest in strained hydrocarbons as potential drug candidates,
we developed a simple and efficient photochemical protocol for (spiro) cyclopropanes from …

ipso-Annulation represents an attractive approach to synthesize a variety of spirocyclic
compounds having a quaternary carbon center. Furthermore, these compounds also serve …

Presented herein is a novel synthesis of homophthalimide spironaphthalenones from the
cascade reaction of enaminones with diazo homophthalimides. Preliminary mechanistic …