Since about 170 years, salts were used to create supersaturated solutions and crystallize
proteins. The dehydrating effect of salts as well as their kosmotropic or chaotropic character …

Rich data bearing on the structural and evolutionary principles of protein–protein
interactions are paving the way to a better understanding of the regulation of function in the …

Experimental detection of residues critical for protein-protein interactions (PPI) is a
timeconsuming, costly, and labor-intensive process. Hence, high-throughput PPI-hot spot …

The aggregation of biotherapeutics is a major hindrance to the development of successful
drug candidates; however, the propensity to aggregate is often identified too late in the …

Monoclonal antibodies (mAbs) are complex molecular structures. They are often prone to
development challenges particularly at high concentrations due to undesired solution …

Predicting protein–protein interaction and non-interaction are two important different aspects
of multi-body structure predictions, which provide vital information about protein function …

Single-point mutations of certain residues (so-called hot spots) impair/disrupt protein–
protein interactions (PPIs), leading to pathogenesis and drug resistance. Conventionally, a …

Background: As a class of membrane protein receptors, G protein-coupled receptors
(GPCRs) are very important for cells to complete normal life function and have been proven …

Drug repurposing is a creative and resourceful approach to increase the number of
therapies by exploiting available and approved drugs. However, identifying new protein …

Accurately predicting protein–protein interaction sites (PPIs) is currently a hot topic because
it has been demonstrated to be very useful for understanding disease mechanisms and …