Rett syndrome and MeCP2

VRB Liyanage, M Rastegar - Neuromolecular medicine, 2014 - Springer
Rett syndrome (RTT) is a severe and progressive neurological disorder, which mainly affects
young females. Mutations of the methyl-CpG binding protein 2 (MECP2) gene are the most …

Murine models for the study of fetal alcohol spectrum disorders: An overview

L Almeida, V Andreu-Fernández… - Frontiers in …, 2020 - frontiersin.org
Prenatal alcohol exposure is associated to different physical, behavioral, cognitive, and
neurological impairments collectively known as fetal alcohol spectrum disorder. The …

Neurological effects of inorganic arsenic exposure: altered cysteine/glutamate transport, NMDA expression and spatial memory impairment

LA Ramos-Chávez, CRR Rendón-López… - Frontiers in cellular …, 2015 - frontiersin.org
Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide
drink water with high levels of iAs. Chronic exposure to iAs has been associated with lower …

Effects of pre-natal alcohol exposure on hippocampal synaptic plasticity: Sex, age and methodological considerations

CJ Fontaine, AR Patten, HM Sickmann, JL Helfer… - Neuroscience & …, 2016 - Elsevier
The consumption of alcohol during gestation is detrimental to the developing central
nervous system (CNS). The severity of structural and functional brain alterations associated …

The benefits of exercise on structural and functional plasticity in the rodent hippocampus of different disease models

AR Patten, SY Yau, CJ Fontaine, A Meconi… - Brain …, 2015 - content.iospress.com
In this review, the benefits of physical exercise on structural and functional plasticity in the
hippocampus are discussed. The evidence is clear that voluntary exercise in rats and mice …

Zebrafish shoaling, its behavioral and neurobiological mechanisms, and its alteration by embryonic alcohol exposure: a review

A Facciol, R Gerlai - Frontiers in behavioral neuroscience, 2020 - frontiersin.org
Social cognition and social behaviors are complex phenomena that involve numerous brain
areas and underlying neurobiological mechanisms. Embryonic alcohol exposure may lead …

Synaptic localization of α5 GABA (A) receptors via gephyrin interaction regulates dendritic outgrowth and spine maturation

ML Brady, TC Jacob - Developmental neurobiology, 2015 - Wiley Online Library
ABSTRACT GABAA receptor subunit composition is a critical determinant of receptor
localization and physiology, with synaptic receptors generating phasic inhibition and …

[HTML][HTML] Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain

JM Lorenz-Guertin, N Povysheva, CA Chapman… - Neurobiology of …, 2023 - Elsevier
Benzodiazepine (BZ) drugs treat seizures, anxiety, insomnia, and alcohol withdrawal by
potentiating γ2 subunit containing GABA type A receptors (GABA A Rs). BZ clinical use is …

Postnatal choline supplementation rescues deficits in synaptic plasticity following prenatal ethanol exposure

EL Grafe, MMM Wade, CE Hodson, JD Thomas… - Nutrients, 2022 - mdpi.com
Prenatal ethanol exposure (PNEE) is a leading cause of neurodevelopmental impairments,
yet treatments for individuals with PNEE are limited. Importantly, postnatal supplementation …

Prenatal ethanol exposure impairs executive function in mice into adulthood

K Marquardt, R Sigdel, K Caldwell… - Alcoholism: Clinical …, 2014 - Wiley Online Library
Background Despite evidence that prenatal alcohol exposure (PAE) can lead to a wide
range of impairments in cognitive, social, and emotional behaviors, drinking during …