Osthole: An overview of its sources, biological activities, and modification development

M Sun, M Sun, J Zhang - Medicinal Chemistry Research, 2021 - Springer
Osthole, also known as osthol, is a coumarin derivative found in several medicinal plants
such as Cnidium monnieri and Angelica pubescens. It can be obtained via extraction and …

Review on the protective activity of osthole against the pathogenesis of osteoporosis

J Chen, X Liao, J Gan - Frontiers in Pharmacology, 2023 - frontiersin.org
Osteoporosis (OP), characterized by continuous bone loss and increased fracture risk, has
posed a challenge to patients and society. Long-term administration of current …

Development of an inflammation-triggered in vitro “leaky gut” model using Caco-2/HT29-MTX-E12 combined with macrophage-like THP-1 cells or primary human …

NPK Le, MJ Altenburger, E Lamy - International Journal of Molecular …, 2023 - mdpi.com
The “leaky gut” syndrome describes a damaged (leaky) intestinal mucosa and is considered
a serious contributor to numerous chronic diseases. Chronic inflammatory bowel diseases …

Establishment of a gut-on-a-chip device with controllable oxygen gradients to study the contribution of Bifidobacterium bifidum to inflammatory bowel disease

J Liu, R Lu, X Zheng, W Hou, X Wu, H Zhao… - Biomaterials …, 2023 - pubs.rsc.org
Supplemental Bifidobacterium has been shown to aid in the prevention, alleviation, and
treatment of inflammatory bowel disease (IBD), but the progression and mechanisms are …

Natural coumarin derivatives activating Nrf2 signaling pathway as lead compounds for the design and synthesis of intestinal anti-inflammatory drugs

LC Di Stasi - Pharmaceuticals, 2023 - mdpi.com
Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor related to stress
response and cellular homeostasis that plays a key role in maintaining the redox system …

Recent Advances in Cell‐Based In Vitro Models to Recreate Human Intestinal Inflammation

MH Macedo, M Dias Neto, L Pastrana… - Advanced …, 2023 - Wiley Online Library
Inflammatory bowel disease causes a major burden to patients and healthcare systems,
raising the need to develop effective therapies. Technological advances in cell culture, allied …

Construction, pesticidal activities, control effects, and detoxification enzyme activities of osthole ester/amide derivatives

M Hao, M Lv, L Zhou, H Li, J Xu… - Journal of Agricultural and …, 2022 - ACS Publications
Pesticide research and development has entered an era of safety, efficiency, and
environmental friendliness. Discovery of effective active products directly or indirectly from …

[HTML][HTML] Citrus Pomace as a Source of Plant Complexes to Be Used in the Nutraceutical Field of Intestinal Inflammation

M Ingegneri, MR Braghini, M Piccione, C De Stefanis… - Antioxidants, 2024 - mdpi.com
This study aims to recover the main by-product of Citrus fruits processing, the raw pomace,
known also as pastazzo, to produce plant complexes to be used in the treatment of …

In Vitro Models for Investigating Intestinal Host–Pathogen Interactions

R McCoy, S Oldroyd, W Yang, K Wang… - Advanced …, 2024 - Wiley Online Library
Infectious diseases are increasingly recognized as a major threat worldwide due to the rise
of antimicrobial resistance and the emergence of novel pathogens. In vitro models that can …

Consumption of honey ameliorates lipopolysaccharide-induced intestinal barrier dysfunction via upregulation of tight junction proteins

S Nathani, N Das, P Katiyar, B Waghmode… - European Journal of …, 2023 - Springer
Purpose The leaky gut barrier is an important factor leading to various inflammatory
gastrointestinal disorders. The nutritional value of honey and variety of its health benefits …