Mechanisms of mesenchymal stem/stromal cell function

JL Spees, RH Lee, CA Gregory - Stem cell research & therapy, 2016 - Springer
The past decade has seen an explosion of research directed toward better understanding of
the mechanisms of mesenchymal stem/stromal cell (MSC) function during rescue and repair …

Peering into tunneling nanotubes—The path forward

D Cordero Cervantes, C Zurzolo - The EMBO journal, 2021 - embopress.org
Abstract The identification of Tunneling Nanotubes (TNTs) and TNT‐like structures signified
a critical turning point in the field of cell‐cell communication. With hypothesized roles in …

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

M Tardivel, S Bégard, L Bousset, S Dujardin… - Acta neuropathologica …, 2016 - Springer
A given cell makes exchanges with its neighbors through a variety of means ranging from
diffusible factors to vesicles. Cells use also tunneling nanotubes (TNTs), filamentous-actin …

Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes

S Abounit, L Bousset, F Loria, S Zhu… - The EMBO …, 2016 - embopress.org
Synucleinopathies such as Parkinson's disease are characterized by the pathological
deposition of misfolded α‐synuclein aggregates into inclusions throughout the central and …

Mechanisms for cell-to-cell transmission of HIV-1

L Bracq, M Xie, S Benichou, J Bouchet - Frontiers in immunology, 2018 - frontiersin.org
While HIV-1 infection of target cells with cell-free viral particles has been largely
documented, intercellular transmission through direct cell-to-cell contact may be a …

α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes

A Dilsizoglu Senol, M Samarani, S Syan… - PLoS …, 2021 - journals.plos.org
The accumulation of α-synuclein (α-syn) aggregates in specific brain regions is a hallmark of
synucleinopathies including Parkinson disease (PD). α-Syn aggregates propagate in a …

Tunneling nanotubes: a possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases

S Abounit, JW Wu, K Duff, GS Victoria, C Zurzolo - Prion, 2016 - Taylor & Francis
The mechanisms of intercellular spreading of amyloidogenic proteins involved in
neurodegenerative diseases have yet to be fully elucidated. While secretion has been …

Tunneling nanotubes: Diversity in morphology and structure

MW Austefjord, HH Gerdes, X Wang - Communicative & integrative …, 2014 - Taylor & Francis
Tunneling nanotubes (TNTs) are recently discovered thin membranous tubes that
interconnect cells. During the last decade, research has shown TNTs to be diverse in …

Tunneling nanotubes and tumor microtubes in cancer

C Roehlecke, MHH Schmidt - Cancers, 2020 - mdpi.com
Intercellular communication among cancer cells and their microenvironment is crucial to
disease progression. The mechanisms by which communication occurs between distant …

B-cell precursor acute lymphoblastic leukemia cells use tunneling nanotubes to orchestrate their microenvironment

R Polak, B de Rooij, R Pieters… - Blood, The Journal of …, 2015 - ashpublications.org
Acute lymphoblastic leukemia (ALL) cells reside in the bone marrow microenvironment
which nurtures and protects cells from chemotherapeutic drugs. The disruption of cell-cell …