Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

The substantial investments in human genetics and genomics made over the past three
decades were anticipated to result in many innovative therapies. Here we investigate the …

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high-
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …

Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …

Alcohol-related liver disease is the most prevalent type of chronic liver disease worldwide,
accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths …

Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease. To
elucidate the molecular basis of NAFLD, we performed an exome-wide association study of …

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in
the Western world and is increasing owing to its close association with obesity and insulin …

Complex traits arise from the interplay between genetic and environmental factors. The
actions of these factors usually appear to be additive, and few compelling examples of gene …

Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using
a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels …

Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects one-
third of adults and an increasing number of children in developed countries. The disease …