The substantial investments in human genetics and genomics made over the past three decades were anticipated to result in many innovative therapies. Here we investigate the …
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high- income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …
Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …
N Ganne-Carrié, P Nahon - Journal of hepatology, 2019 - Elsevier
Alcohol-related liver disease is the most prevalent type of chronic liver disease worldwide, accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths …
Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease. To elucidate the molecular basis of NAFLD, we performed an exome-wide association study of …
T Hardy, F Oakley, QM Anstee… - Annual review of …, 2016 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in the Western world and is increasing owing to its close association with obesity and insulin …
Complex traits arise from the interplay between genetic and environmental factors. The actions of these factors usually appear to be additive, and few compelling examples of gene …
Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels …
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects one- third of adults and an increasing number of children in developed countries. The disease …