Translation regulation largely occurs during initiation, which features ribosome assembly
onto mRNAs and selection of the translation start site. Short, upstream ORFs (uORFs) …

Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily
conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in …

Aroma compounds provide attractiveness and variety to alcoholic beverages. We discuss
the molecular biology of a major subset of beer aroma volatiles, fruity and floral compounds …

The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies
on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been …

The natural environment for plants is composed of a complex set of abiotic stresses and
biotic stresses. Plant responses to these stresses are equally complex. Systems biology …

Ever since the beginning of biochemical analysis, yeast has been a pioneering model for
studying the regulation of eukaryotic metabolism. During the last three decades, the …

For organisms to coordinate their growth and development with nutrient availability, they
must be able to sense nutrient levels in their environment. Here, we review select nutrient …

Tryptophan catabolism by indoleamine 2, 3-dioxygenase (IDO) alters inflammation and
favors T-cell tolerance in cancer, but the underlying molecular mechanisms remain poorly …

The protein kinase Gcn2 is present in virtually all eukaryotes and is of increasing interest
due to its involvement in a large array of crucial biological processes. Some of these are …

Genome-wide phenotypic screens in the budding yeast Saccharomyces cerevisiae, enabled
by its knockout collection, have produced the largest, richest, and most systematic …